Pias2 - protein inhibitor of activated STAT, 2 Gene

Also Known as DIP; Miz1; ARIP3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83422

Summary

Enables nuclear receptor binding activity and protein domain specific binding activity. Involved in several processes, including Androgen Receptor signaling pathway; positive regulation of dendrite morphogenesis; and response to testosterone. Acts upstream of or within regulation of Androgen Receptor signaling pathway. Located in nucleus. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2). [provided by Alliance of Genome Resources, Apr 2022]

Pias2 Products (2)

mRNA Protein Name
NM_001393764.1 NP_001380693.1 E3 SUMO-protein ligase PIAS2 isoform 1
NM_053337.2 NP_445789.2 E3 SUMO-protein ligase PIAS2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear androgen receptor binding IPI
IPI: Inferred from physical interaction
9920921 RGD
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
11117529 RGD
enables nuclear glucocorticoid receptor binding IPI
IPI: Inferred from physical interaction
11117529 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16144832 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
19198660 RGD
Biological Process GO Annotation Evidence References Source
involved in androgen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9920921 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
9920921 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
17855618 RGD
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11117529 RGD
acts upstream of or within regulation of androgen receptor signaling pathway IDA
IDA: Inferred from direct assay
9920921 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
12799075 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
12799075 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9920921 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 SUMO-protein ligase PIAS2

  • DAB2-interacting protein

  • E3 SUMO-protein transferase PIAS2

  • androgen receptor-interacting protein 3

  • msx-interacting-zinc finger protein

  • protein inhibitor of activated STAT x

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10474 PIAS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22729 Pias2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pias2 NCBI NCBI:9063