Pias2 - protein inhibitor of activated STAT, 2 Gene

Rattus norvegicus

Also known as DIP; Miz1; ARIP3

Gene ID: 83422 | Gene type: protein coding

About Pias2

Summary

Enables nuclear receptor binding activity and protein domain specific binding activity. Involved in several processes, including Androgen Receptor signaling pathway; positive regulation of dendrite morphogenesis; and response to testosterone. Acts upstream of or within regulation of Androgen Receptor signaling pathway. Located in nucleus. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2). [provided by Alliance of Genome Resources, Apr 2022]

Pias2 Products(2)

mRNA	Protein	Name
NM_001393764.1	NP_001380693.1	E3 SUMO-protein ligase PIAS2 isoform 1
NM_053337.2	NP_445789.2	E3 SUMO-protein ligase PIAS2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear androgen receptor binding	IPI IPI: Inferred from physical interaction	9920921	RGD
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	11117529	RGD
enables nuclear glucocorticoid receptor binding	IPI IPI: Inferred from physical interaction	11117529	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16144832	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	19198660	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9920921	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	9920921	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	17855618	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11117529	RGD
acts upstream of or within regulation of androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	9920921	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	12799075	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	12799075	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9920921	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 SUMO-protein ligase PIAS2

DAB2-interacting protein	E3 SUMO-protein transferase PIAS2
androgen receptor-interacting protein 3	msx-interacting-zinc finger protein
protein inhibitor of activated STAT x

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10474	PIAS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22729	Pias2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pias2	NCBI	NCBI:9063

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