Akap12 - A-kinase anchoring protein 12 Gene

Also Known as AKAP12A; AKAP12B; AKAP12G

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83425

Summary

Predicted to enable Adenylate Cyclase binding activity. Involved in several processes, including cellular response to cytokine stimulus; hepatic stellate cell activation; and positive regulation of macromolecule metabolic process. Located in cytoplasm and neuronal cell body. Biomarker of brain ischemia; liver cirrhosis; osteosarcoma; and sciatic neuropathy. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12). [provided by Alliance of Genome Resources, Apr 2022]

Akap12 Products (2)

mRNA Protein Name
NM_001033653.1 NP_001028825.1 A-kinase anchor protein 12 isoform beta
NM_057103.2 NP_476444.2 A-kinase anchor protein 12 isoform alpha

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
20454828 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
20454828 RGD
involved in hepatic stellate cell activation IEP
IEP: Inferred from expression pattern
23925424 RGD
involved in negative regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
20454828 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
19937403 RGD
involved in positive regulation of hepatic stellate cell migration IMP
IMP: Inferred from mutant phenotype
23925424 RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process IMP
IMP: Inferred from mutant phenotype
19937403 RGD
involved in positive regulation of oligodendrocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
20155814 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
17873284 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
23912647 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
23912647 RGD
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
11814414 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A-kinase anchor protein 12

  • A kinase (PRKA) anchor protein (gravin) 12

  • A kinase (PRKA) anchor protein 12

  • AKAP-12

  • SSeCKS, Gravin, AKAP250

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00515 AKAP12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akap12 NCBI NCBI:9590