Akap12 - A-kinase anchoring protein 12 Gene

Rattus norvegicus

Also known as AKAP12A; AKAP12B; AKAP12G

Gene ID: 83425 | Gene type: protein coding

About Akap12

Summary

Predicted to enable Adenylate Cyclase binding activity. Involved in several processes, including cellular response to cytokine stimulus; hepatic stellate cell activation; and positive regulation of macromolecule metabolic process. Located in cytoplasm and neuronal cell body. Biomarker of brain ischemia; liver cirrhosis; osteosarcoma; and sciatic neuropathy. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12). [provided by Alliance of Genome Resources, Apr 2022]

Akap12 Products(2)

mRNA	Protein	Name
NM_001033653.1	NP_001028825.1	A-kinase anchor protein 12 isoform beta
NM_057103.2	NP_476444.2	A-kinase anchor protein 12 isoform alpha

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	20454828	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	20454828	RGD
involved in hepatic stellate cell activation	IEP IEP: Inferred from expression pattern	23925424	RGD
involved in negative regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	20454828	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19937403	RGD
involved in positive regulation of hepatic stellate cell migration	IMP IMP: Inferred from mutant phenotype	23925424	RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	19937403	RGD
involved in positive regulation of oligodendrocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	20155814	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	17873284	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	23912647	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	23912647	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in neuronal cell body	IDA IDA: Inferred from direct assay	11814414	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A-kinase anchor protein 12

A kinase (PRKA) anchor protein (gravin) 12	A kinase (PRKA) anchor protein 12
AKAP-12	SSeCKS, Gravin, AKAP250

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00515	AKAP12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Akap12	NCBI	NCBI:9590

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