SCRT1 - scratch family transcriptional repressor 1 Gene

Also Known as SCRT; ZNF898

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83482

About SCRT1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,330,565-144,336,482 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 238 orthologues and 36 paralogues. Biased expression in brain (RPKM 4.1), adrenal (RPKM 0.6) and 1 other tissue.

Summary

This gene encodes a C2H2-type zinc finger transcriptional repressor that binds to E-box motifs. The encoded protein may promote neural differention and may be involved in cancers with neuroendocrine features. [provided by RefSeq, Jul 2013]

SCRT1 Products (1)

mRNA Protein Name
NM_031309.6 NP_112599.2 transcriptional repressor scratch 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11274425 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11274425 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23332764 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11274425 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCRT1 Protein Structure

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (191 - 213)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (223 - 244)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (263 - 286)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (290 - 314)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
Protein Preferred Names Protein Names

transcriptional repressor scratch 1

  • scratch family zinc finger 1

Related Diseases

Diseases Alias
Fumarase Deficiency

  • Fumaric Aciduria

  • FMRD

  • Fumarate Hydratase Deficiency

  • Deficiency, Fumarase
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12565 SCRT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SCRT1 VGNC VGNC:34369
Mus musculus SCRT1 MGD MGI:2176606
Rattus norvegicus SCRT1 RGD RGD:1306236
Macaca mulatta SCRT1 VGNC VGNC:77021
Others SCRT1 NCBI