Cdh2 - cadherin 2 Gene

Also Known as N-cadherin

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 83501

Summary

Enables beta-catenin binding activity; nitric-oxide synthase binding activity; and protein kinase binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; regulation of glutamatergic synaptic transmission; and regulation of myelination. Located in several cellular components, including T-tubule; adherens junction; and fascia adherens. Is integral component of postsynaptic specialization membrane and integral component of presynaptic active zone membrane. Part of protein-containing complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in agenesis of corpus callosum, cardiac, ocular, and genital syndrome; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 14. Orthologous to human CDH2 (Cadherin 2). [provided by Alliance of Genome Resources, Apr 2022]

Cdh2 Products (1)

mRNA	Protein	Name
NM_031333.2	NP_112623.2	cadherin-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	12533412	RGD
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	15858215	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10753743	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12700184	RGD
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	12700184	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	8834786	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IMP IMP: Inferred from mutant phenotype	11414796	RGD
involved in cell-cell adhesion	IDA IDA: Inferred from direct assay	12533412	RGD
involved in modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	9655504	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	9655504	RGD
involved in regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	16515795	RGD
involved in regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	12657688	RGD
involved in regulation of myelination	IMP IMP: Inferred from mutant phenotype	11414796	RGD
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	16515795	RGD
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	12125071	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in T-tubule	IDA IDA: Inferred from direct assay	15579534	RGD
located in adherens junction	IDA IDA: Inferred from direct assay	8834786	RGD
located in desmosome	IDA IDA: Inferred from direct assay	21617128	RGD
located in fascia adherens	IDA IDA: Inferred from direct assay	16515795	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	9655504	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9655504	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	15579534	RGD
located in membrane	IDA IDA: Inferred from direct assay	19723622	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	18179895	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	12533412	RGD
located in synapse	IDA IDA: Inferred from direct assay	18179895	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cadherin-2	cadherin 2, type 1, N-cadherin (neuronal) neural cadherin

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02330	CDH2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17634	Cdh2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24094	Cdh2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdh2	NCBI	NCBI:1000