Kcnj11 - potassium inwardly-rectifying channel, subfamily J, member 11 Gene

Rattus norvegicus

Also known as Kir6.2

Gene ID: 83535 | Gene type: protein coding

About Kcnj11

Summary

Enables several functions, including ankyrin binding activity; inorganic cation transmembrane transporter activity; and protein C-terminus binding activity. Involved in several processes, including cation transport; cellular response to nicotine; and response to ischemia. Located in several cellular components, including axolemma; cell body fiber; and cytoplasmic vesicle. Part of inward rectifying Potassium Channel. Biomarker of brain disease (multiple); glucose metabolism disease (multiple); hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 2 and glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj11 Products(1)

mRNA	Protein	Name
NM_031358.3	NP_112648.2	ATP-sensitive inward rectifier potassium channel 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP-activated inward rectifier potassium channel activity	IDA IDA: Inferred from direct assay	17097686	RGD
enables ATP-activated inward rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	15163199	RGD
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	28842488	RGD
enables ankyrin binding	IPI IPI: Inferred from physical interaction	19805355	RGD
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	20427569	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19181933	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	14672537	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	19720793	RGD
involved in cellular response to nicotine	IEP IEP: Inferred from expression pattern	22403787	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	19460779	RGD
involved in inorganic cation transmembrane transport	IGI IGI: Inferred from genetic interaction	28842488	RGD
involved in positive regulation of cation channel activity	IMP IMP: Inferred from mutant phenotype	23785408	RGD
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	23695995	RGD
involved in potassium ion import across plasma membrane	IDA IDA: Inferred from direct assay	8630239	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	17097686	RGD
involved in potassium ion transport	IMP IMP: Inferred from mutant phenotype	16048905	RGD
involved in response to ATP	IGI IGI: Inferred from genetic interaction	28842488	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	23032400	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	20971764	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	18950632	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15964031	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	15647111	RGD
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	21328565	RGD
located in axolemma	IDA IDA: Inferred from direct assay	20102598	RGD
located in cell body fiber	IDA IDA: Inferred from direct assay	20102598	RGD
located in endosome	IDA IDA: Inferred from direct assay	20971764	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17883401	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	23066018	RGD
part of inward rectifying potassium channel	IDA IDA: Inferred from direct assay	17097686	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	20102598	RGD
located in nuclear envelope	IDA IDA: Inferred from direct assay	20102598	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	17883401	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	12738227	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-sensitive inward rectifier potassium channel 11

BIR	inward rectifier K(+) channel Kir6.2
potassium channel, inwardly rectifying subfamily J member 11	potassium voltage-gated channel subfamily J member 11

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07138	KCNJ11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnj11	NCBI	NCBI:3767

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