Kcnj11 - potassium inwardly-rectifying channel, subfamily J, member 11 Gene

Also Known as Kir6.2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83535

Summary

Enables several functions, including ankyrin binding activity; inorganic cation transmembrane transporter activity; and protein C-terminus binding activity. Involved in several processes, including cation transport; cellular response to nicotine; and response to ischemia. Located in several cellular components, including axolemma; cell body fiber; and cytoplasmic vesicle. Part of inward rectifying Potassium Channel. Biomarker of brain disease (multiple); glucose metabolism disease (multiple); hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 2 and glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj11 Products (1)

mRNA Protein Name
NM_031358.3 NP_112648.2 ATP-sensitive inward rectifier potassium channel 11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-activated inward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
17097686 RGD
enables ATP-activated inward rectifier potassium channel activity IMP
IMP: Inferred from mutant phenotype
15163199 RGD
enables ATPase-coupled monoatomic cation transmembrane transporter activity IGI
IGI: Inferred from genetic interaction
28842488 RGD
enables ankyrin binding IPI
IPI: Inferred from physical interaction
19805355 RGD
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
20427569 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19181933 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
14672537 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
19720793 RGD
involved in cellular response to nicotine IEP
IEP: Inferred from expression pattern
22403787 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
19460779 RGD
involved in inorganic cation transmembrane transport IGI
IGI: Inferred from genetic interaction
28842488 RGD
involved in positive regulation of cation channel activity IMP
IMP: Inferred from mutant phenotype
23785408 RGD
involved in positive regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
23695995 RGD
involved in potassium ion import across plasma membrane IDA
IDA: Inferred from direct assay
8630239 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
17097686 RGD
involved in potassium ion transport IMP
IMP: Inferred from mutant phenotype
16048905 RGD
involved in response to ATP IGI
IGI: Inferred from genetic interaction
28842488 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
23032400 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
20971764 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
18950632 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15964031 RGD
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
15647111 RGD
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
21328565 RGD
located in axolemma IDA
IDA: Inferred from direct assay
20102598 RGD
located in cell body fiber IDA
IDA: Inferred from direct assay
20102598 RGD
located in endosome IDA
IDA: Inferred from direct assay
20971764 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17883401 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
23066018 RGD
part of inward rectifying potassium channel IDA
IDA: Inferred from direct assay
17097686 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
20102598 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
20102598 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
17883401 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
12738227 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-sensitive inward rectifier potassium channel 11

  • BIR

  • inward rectifier K(+) channel Kir6.2

  • potassium channel, inwardly rectifying subfamily J member 11

  • potassium voltage-gated channel subfamily J member 11

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07138 KCNJ11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnj11 NCBI NCBI:3767