Smpd2 - sphingomyelin phosphodiesterase 2 Gene

Also Known as nSMase

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83537

Summary

Enables sphingomyelin phosphodiesterase activity. Involved in ceramide biosynthetic process; intracellular signal transduction; and response to mechanical stimulus. Located in caveola. Orthologous to human SMPD2 (sphingomyelin phosphodiesterase 2). [provided by Alliance of Genome Resources, Apr 2022]

Smpd2 Products (1)

mRNA Protein Name
NM_031360.2 NP_112650.1 sphingomyelin phosphodiesterase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sphingomyelin phosphodiesterase activity IDA
IDA: Inferred from direct assay
10832103 RGD
Biological Process GO Annotation Evidence References Source
involved in ceramide biosynthetic process IDA
IDA: Inferred from direct assay
12473648 RGD
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
12473648 RGD
involved in response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
12473648 RGD
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
12473648 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sphingomyelin phosphodiesterase 2

  • N-SMase

  • lyso-PAF-PLC

  • lyso-platelet-activating factor-phospholipase C

  • neutral sphingomyelinase

  • sphingomyelin phosphodiesterase 2, neutral membrane

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134505 Avicin G Inhibitor / Unkown
HY-RS13448 SMPD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smpd2 NCBI NCBI:6610