2. Gene
  3. Smpd2 - sphingomyelin phosphodiesterase 2 Gene

Smpd2 - sphingomyelin phosphodiesterase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as nSMase

Gene ID: 83537 | Gene type: protein coding

About Smpd2

Summary

Enables sphingomyelin phosphodiesterase activity. Involved in ceramide biosynthetic process; intracellular signal transduction; and response to mechanical stimulus. Located in caveola. Orthologous to human SMPD2 (sphingomyelin phosphodiesterase 2). [provided by Alliance of Genome Resources, Apr 2022]

Smpd2 Products(1)

mRNA Protein Name
NM_031360.2 NP_112650.1 sphingomyelin phosphodiesterase 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables sphingomyelin phosphodiesterase activity IDA
IDA: Inferred from direct assay
10832103 RGD
Biological Process GO Annotation Evidence Reference Source
involved in ceramide biosynthetic process IDA
IDA: Inferred from direct assay
12473648 RGD
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
12473648 RGD
involved in response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
12473648 RGD
Cellular Component GO Annotation Evidence Reference Source
located in caveola IDA
IDA: Inferred from direct assay
12473648 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sphingomyelin phosphodiesterase 2

N-SMase

lyso-PAF-PLC

lyso-platelet-activating factor-phospholipase C

neutral sphingomyelinase

sphingomyelin phosphodiesterase 2, neutral membrane

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-134505 Avicin G Inhibitor / Unkown
HY-RS13448 SMPD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smpd2 NCBI NCBI:6610