Pafah1b1 - platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 Gene

Also Known as LIS1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83572

Summary

Enables dynein intermediate chain binding activity. Involved in several processes, including establishment of centrosome localization; generation of neurons; and negative regulation of neuron projection development. Located in several cellular components, including central region of growth cone; neuronal cell body; and nuclear envelope. Part of 1-alkyl-2-acetylglycerophosphocholine esterase complex and Kinesin complex. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in lissencephaly and lissencephaly 1. Orthologous to human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Pafah1b1 Products (1)

mRNA Protein Name
NM_031763.3 NP_113951.1 platelet-activating factor acetylhydrolase IB subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables dynein intermediate chain binding IDA
IDA: Inferred from direct assay
11056530 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9601647 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17202468 RGD
Biological Process GO Annotation Evidence References Source
involved in cerebral cortex neuron differentiation IMP
IMP: Inferred from mutant phenotype
16144905 RGD
involved in establishment of centrosome localization IMP
IMP: Inferred from mutant phenotype
17618279 RGD
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
18075262 RGD
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
16144905 RGD
involved in nuclear migration IMP
IMP: Inferred from mutant phenotype
17618279 RGD
involved in positive regulation of axon extension IMP
IMP: Inferred from mutant phenotype
17202468 RGD
involved in positive regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
11056532 RGD
involved in stem cell division IMP
IMP: Inferred from mutant phenotype
16144905 RGD
Cellular Component GO Annotation Evidence References Source
part of 1-alkyl-2-acetylglycerophosphocholine esterase complex IDA
IDA: Inferred from direct assay
9660828 RGD
located in axon IDA
IDA: Inferred from direct assay
17202468 RGD
located in central region of growth cone IDA
IDA: Inferred from direct assay
17202468 RGD
located in growth cone IDA
IDA: Inferred from direct assay
11056530 RGD
part of kinesin complex IDA
IDA: Inferred from direct assay
17202468 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11056530 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
18809722 RGD
located in vesicle IDA
IDA: Inferred from direct assay
11056530 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

platelet-activating factor acetylhydrolase IB subunit alpha

  • LIS-1

  • PAF acetylhydrolase 45 kDa subunit

  • PAF-AH 45 kDa subunit

  • PAF-AH alpha

  • PAF-AH beta

  • PAFAH alpha

  • lissencephaly-1 protein

  • platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09967 PAFAH1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pafah1b1 NCBI NCBI:5048