Pafah1b1 - platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 Gene

Rattus norvegicus

Also known as LIS1

Gene ID: 83572 | Gene type: protein coding

About Pafah1b1

Summary

Enables dynein intermediate chain binding activity. Involved in several processes, including establishment of centrosome localization; generation of neurons; and negative regulation of neuron projection development. Located in several cellular components, including central region of growth cone; neuronal cell body; and nuclear envelope. Part of 1-alkyl-2-acetylglycerophosphocholine esterase complex and Kinesin complex. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in lissencephaly and lissencephaly 1. Orthologous to human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Pafah1b1 Products(1)

mRNA	Protein	Name
NM_031763.3	NP_113951.1	platelet-activating factor acetylhydrolase IB subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables dynein intermediate chain binding	IDA IDA: Inferred from direct assay	11056530	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9601647	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17202468	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cerebral cortex neuron differentiation	IMP IMP: Inferred from mutant phenotype	16144905	RGD
involved in establishment of centrosome localization	IMP IMP: Inferred from mutant phenotype	17618279	RGD
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	18075262	RGD
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	16144905	RGD
involved in nuclear migration	IMP IMP: Inferred from mutant phenotype	17618279	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	17202468	RGD
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	11056532	RGD
involved in stem cell division	IMP IMP: Inferred from mutant phenotype	16144905	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of 1-alkyl-2-acetylglycerophosphocholine esterase complex	IDA IDA: Inferred from direct assay	9660828	RGD
located in axon	IDA IDA: Inferred from direct assay	17202468	RGD
located in central region of growth cone	IDA IDA: Inferred from direct assay	17202468	RGD
located in growth cone	IDA IDA: Inferred from direct assay	11056530	RGD
part of kinesin complex	IDA IDA: Inferred from direct assay	17202468	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	11056530	RGD
located in nuclear envelope	IDA IDA: Inferred from direct assay	18809722	RGD
located in vesicle	IDA IDA: Inferred from direct assay	11056530	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

platelet-activating factor acetylhydrolase IB subunit alpha

LIS-1	PAF acetylhydrolase 45 kDa subunit
PAF-AH 45 kDa subunit	PAF-AH alpha
PAF-AH beta	PAFAH alpha
lissencephaly-1 protein	platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta)

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09967	PAFAH1B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pafah1b1	NCBI	NCBI:5048

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