AKR1E2 - aldo-keto reductase family 1 member E2 Gene

Also Known as TAKR; hTSP; HTSP1; htAKR; AKRDC1; AKR1CL2; LoopADR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83592

About AKR1E2

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:4,824,973-4,873,237 (from NCBI)

This gene has 13 transcripts (splice variants), 350 orthologues, 16 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 4.3), thyroid (RPKM 0.6) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

AKR1E2 Products (3)

mRNA Protein Name
NM_001040177.3 NP_001035267.1 1,5-anhydro-D-fructose reductase isoform 1
NM_001271021.2 NP_001257950.1 1,5-anhydro-D-fructose reductase isoform 2
NM_001271025.2 NP_001257954.1 1,5-anhydro-D-fructose reductase isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables oxidoreductase activity IDA
IDA: Inferred from direct assay
15118078 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR1E2 Protein Structure

Aldo_ket_red

Aldo_ket_red: Aldo/keto reductase family (13 - 297)

  • 0
  • 100
  • 200
  • 300
  • 320 a.a.
Protein Preferred Names Protein Names

1,5-anhydro-D-fructose reductase

  • AF reductase

Related Diseases

Diseases Alias
Cataract 18

  • Cataract, Autosomal Recessive Congenital 2

  • Catc2

  • CTRCT18

  • Autosomal Recessive Congenital Cataract 2

  • Cataract 18, Autosomal Recessive

  • Cataract 18 Autosomal Recessive

  • Cataract, Type 18
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00539 AKR1E2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28336 Akr1e2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus AKR1E2 VGNC VGNC:59726
Mus musculus AKR1E2 MGD MGI:1914758
Canis familiaris AKR1E2 VGNC VGNC:37769
Rattus norvegicus AKR1E2 RGD RGD:1309599
Macaca mulatta AKR1E2 VGNC VGNC:69674
Bos taurus AKR1E2 VGNC VGNC:57038
Others AKR1E2 NCBI