2. Gene
  3. Cngb1 - cyclic nucleotide gated channel subunit beta 1 Gene

Cngb1 - cyclic nucleotide gated channel subunit beta 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Gm1959

Gene ID: 83686 | Gene type: protein coding

About Cngb1

Summary

Enables intracellular cAMP-activated cation channel activity and intracellular cGMP-activated cation channel activity. Involved in regulation of cytosolic calcium ion concentration. Located in plasma membrane and terminal bouton. Part of intracellular cyclic nucleotide activated cation channel complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 45. Orthologous to human CNGB1 (cyclic nucleotide gated channel subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Cngb1 Products(2)

mRNA Protein Name
NM_001389260.1 NP_001376189.1 cyclic nucleotide-gated cation channel beta-1 isoform 2
NM_031809.2 NP_113997.2 cyclic nucleotide-gated cation channel beta-1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cAMP binding IDA
IDA: Inferred from direct assay
27405959 RGD
enables cGMP binding IDA
IDA: Inferred from direct assay
27405959 RGD
enables intracellularly cAMP-activated cation channel activity IDA
IDA: Inferred from direct assay
10377344 RGD
enables intracellularly cGMP-activated cation channel activity IDA
IDA: Inferred from direct assay
9878057 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
22786723 RGD
Biological Process GO Annotation Evidence Reference Source
involved in calcium ion transport IDA
IDA: Inferred from direct assay
9878057 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
10377344 RGD
involved in regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
21809342 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
10377344 RGD
Cellular Component GO Annotation Evidence Reference Source
part of intracellular cyclic nucleotide activated cation channel complex IDA
IDA: Inferred from direct assay
21809342 RGD
located in non-motile cilium membrane IDA
IDA: Inferred from direct assay
10377344 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
21809342 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclic nucleotide-gated cation channel beta-1

cyclic nucleotide gated channel beta 1

cyclic nucleotide-gated channel beta subunit 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02883 CNGB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cngb1 NCBI NCBI:1258