Akr1c6 - aldo-keto reductase family 1, member C6 Gene

Also Known as Akr1c1; Hsd17b5; 3alpha-HSD

Species: Mus musculus

Gene Type: protein coding
Gene ID: 83702

Summary

Enables estradiol 17-beta-dehydrogenase activity. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and steroid metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; liver and biliary system; lung; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1) and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2022]

Akr1c6 Products (1)

mRNA Protein Name
NM_030611.3 NP_085114.1 estradiol 17 beta-dehydrogenase 5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables aldo-keto reductase (NADPH) activity IDA
IDA: Inferred from direct assay
12562828 MGI
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
7737980 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
23636947 MGI
involved in steroid biosynthetic process IDA
IDA: Inferred from direct assay
12562828 MGI
acts upstream of or within steroid metabolic process IDA
IDA: Inferred from direct assay
7737980 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

estradiol 17 beta-dehydrogenase 5

  • 17-beta-HSD 5

  • 17HSD type 5

  • aldo-keto reductase family 1, member C1 (aldehyde reductase)

  • estradiol 17-beta-dehydrogenase (A-specific)

  • hydroxysteroid 17-beta dehydrogenase 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS23471 Akr1c1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown