2. Gene
  3. ARMC10 - armadillo repeat containing 10 Gene

ARMC10 - armadillo repeat containing 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SVH; PNAS112; PNAS-112; PSEC0198

Gene ID: 83787 | Gene type: protein coding

About ARMC10

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:103,075,140-103,099,759 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 132 orthologues and 11 paralogues. Ubiquitous expression in thyroid (RPKM 11.8), adrenal (RPKM 9.8) and 25 other tissues.

Summary

This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]

ARMC10 Products(6)

mRNA Protein Name
NM_001161009.3 NP_001154481.1 armadillo repeat-containing protein 10 isoform b
NM_001161010.3 NP_001154482.1 armadillo repeat-containing protein 10 isoform c
NM_001161011.3 NP_001154483.1 armadillo repeat-containing protein 10 isoform e
NM_001161012.3 NP_001154484.1 armadillo repeat-containing protein 10 isoform d
NM_001161013.3 NP_001154485.1 armadillo repeat-containing protein 10 isoform f
NM_031905.5 NP_114111.2 armadillo repeat-containing protein 10 isoform a

ARMC10 Protein Structure

Arm_2

Arm_2: Armadillo-like (86 - 337)

  • 0
  • 100
  • 200
  • 300
  • 343 a.a.
Protein Preferred Names Protein Names

armadillo repeat-containing protein 10

specific splicing variant involved in hepatocarcinogenesis

Related Diseases

Diseases Alias
Vitreoretinal Degeneration, Snowflake Type

Snowflake Vitreoretinal Degeneration

SVD

Snowflake Degeneration In Hereditary Vitreoretinal Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01001 ARMC10 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARMC10 RGD RGD:1305915
Canis familiaris ARMC10 VGNC VGNC:97185
Bos taurus ARMC10 VGNC VGNC:50079
Felis catus ARMC10 VGNC VGNC:69348
Mus musculus ARMC10 MGD MGI:1914461
Macaca mulatta ARMC10 VGNC VGNC:69879