TTC29 - tetratricopeptide repeat domain 29 Gene

Also Known as SPGF42; TBPP2A; NYD-SP14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83894

About TTC29

Cytogenetic location: 4q31.22 Genomic coordinates (GRCh38): 4:146,706,617-146,945,864 (from NCBI)

This gene has 8 transcripts (splice variants), 158 orthologues, 6 paralogues and is associated with 2 phenotypes. Restricted expression toward testis (RPKM 35.8).

Summary

Involved in cilium movement and cilium organization. Located in sperm flagellum. Implicated in spermatogenic failure 42. [provided by Alliance of Genome Resources, Apr 2022]

TTC29 Products (3)

mRNA	Protein	Name
NM_001300761.4	NP_001287690.1	tetratricopeptide repeat protein 29 isoform 1
NM_001317806.3	NP_001304735.1	tetratricopeptide repeat protein 29 isoform 3
NM_031956.4	NP_114162.2	tetratricopeptide repeat protein 29 isoform 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in cilium movement	IDA IDA: Inferred from direct assay	31735292	GOA
involved in cilium movement	IMP IMP: Inferred from mutant phenotype	31735294	GOA
involved in cilium organization	IDA IDA: Inferred from direct assay	31735292	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in sperm flagellum	IDA IDA: Inferred from direct assay	31735292	GOA
located in sperm flagellum	IMP IMP: Inferred from mutant phenotype	31735294	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTC29 Protein Structure

TPR_2

TPR_12

0
100
200
300
400
475 a.a.

Protein Preferred Names	Protein Names
tetratricopeptide repeat protein 29	TPR repeat protein 29

Related Diseases

Diseases	Alias
Spermatogenic Failure 42	SPGF42
Non-Syndromic Male Infertility Due To Sperm Motility Disorder	Non-Syndromic Male Infertility Due Asthenozoospermia
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Infertility
Male Infertility Due To Acephalic Spermatozoa	Acephalic Spermatozoa Syndrome
Oligoasthenoteratozoospermia	Oat Oligoasthenoteratospermia
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15207	TTC29 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TTC29	RGD	RGD:1589777
Canis familiaris	TTC29	VGNC	VGNC:47949
Felis catus	TTC29	VGNC	VGNC:66665
Mus musculus	TTC29	MGD	MGI:1920551
Macaca mulatta	TTC29	VGNC	VGNC:82262
Bos taurus	TTC29	VGNC	VGNC:36468
Others	TTC29	NCBI