Eif2b2 - eukaryotic translation initiation factor 2B subunit beta Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84005

Summary

Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including nervous system development; response to glucose; and response to heat. Located in axon. Part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B2 (eukaryotic translation initiation factor 2B subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Eif2b2 Products (1)

mRNA Protein Name
NM_032058.2 NP_114447.2 translation initiation factor eIF-2B subunit beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
9582312 RGD
Biological Process GO Annotation Evidence References Source
involved in hippocampus development IEP
IEP: Inferred from expression pattern
12850562 RGD
involved in positive regulation of axon extension IMP
IMP: Inferred from mutant phenotype
23616526 RGD
involved in response to glucose IDA
IDA: Inferred from direct assay
8567668 RGD
involved in response to heat IDA
IDA: Inferred from direct assay
9341116 RGD
involved in response to peptide hormone IDA
IDA: Inferred from direct assay
8430778 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
23616526 RGD
is active in endoplasmic reticulum IDA
IDA: Inferred from direct assay
9870948 RGD
part of eukaryotic translation initiation factor 2B complex IDA
IDA: Inferred from direct assay
9631509 RGD
is active in glycinergic synapse IDA
IDA: Inferred from direct assay
9870948 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
9870948 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

translation initiation factor eIF-2B subunit beta

  • eIF-2B GDP-GTP exchange factor subunit beta

  • eukaryotic translation initiation factor 2B subunit 2

  • eukaryotic translation initiation factor 2B, subunit 2 (beta, 39kD)

  • eukaryotic translation initiation factor 2B, subunit 2 beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04249 EIF2B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif2b2 NCBI NCBI:8892