Slc1a6 - solute carrier family 1 member 6 Gene

Rattus norvegicus

Also known as EAAT4

Gene ID: 84012 | Gene type: protein coding

About Slc1a6

Summary

Enables high-affinity glutamate transmembrane transporter activity. Involved in L-glutamate import across plasma membrane. Is integral component of plasma membrane. Part of membrane protein complex. Is active in parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic membrane. Orthologous to human SLC1A6 (solute carrier family 1 member 6). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a6 Products(1)

mRNA	Protein	Name
NM_032065.2	NP_114454.2	excitatory amino acid transporter 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables high-affinity L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	26690923	RGD
enables monoatomic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	11950769	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-glutamate import across plasma membrane	IDA IDA: Inferred from direct assay	26690923	RGD
involved in L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	26690923	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of membrane protein complex	IDA IDA: Inferred from direct assay	9334410	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	9570792	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	26690923	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	9570792	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

excitatory amino acid transporter 4

high affinity aspartate/glutamate transporter	high-affinity neuronal glutamate transporter
sodium-dependent glutamate/aspartate transporter	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13057	SLC1A6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc1a6	NCBI	NCBI:6511

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