Synj2 - synaptojanin 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84018

Summary

Enables Phosphatase activity and protein domain specific binding activity. Involved in brain development; dephosphorylation; and intracellular distribution of mitochondria. Located in several cellular components, including cytoplasmic microtubule; perinuclear region of cytoplasm; and ruffle membrane. Is extrinsic component of mitochondrial outer membrane. Is active in presynapse. Orthologous to human SYNJ2 (synaptojanin 2). [provided by Alliance of Genome Resources, Apr 2022]

Synj2 Products (3)

mRNA Protein Name
NM_001113371.1 NP_001106842.1 synaptojanin-2 isoform 1
NM_001113372.1 NP_001106843.1 synaptojanin-2 isoform 2
NM_032071.3 NP_114460.2 synaptojanin-2 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables PDZ domain binding IPI
IPI: Inferred from physical interaction
11498538 RGD
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
10357812 RGD
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
11498538 RGD
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IDA
IDA: Inferred from direct assay
9388224 RGD
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IDA
IDA: Inferred from direct assay
9388224 RGD
enables phosphatidylinositol monophosphate phosphatase activity IDA
IDA: Inferred from direct assay
11498538 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9388224 RGD
Biological Process GO Annotation Evidence References Source
involved in inositol phosphate catabolic process IDA
IDA: Inferred from direct assay
9388224 RGD
involved in phosphatidylinositol dephosphorylation IDA
IDA: Inferred from direct assay
11498538 RGD
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
11498538 RGD
located in cytoplasmic microtubule IDA
IDA: Inferred from direct assay
11498538 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
11498538 RGD
located in ruffle membrane IDA
IDA: Inferred from direct assay
11498538 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptojanin-2

  • synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141659 CMPD-39 99.74% Unkown
HY-141659A (R)-CMPD-39 99.78% Unkown
HY-RS14094 SYNJ2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14095 SYNJ2BP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Synj2 NCBI NCBI:8871