SRPX - sushi repeat containing protein X-linked Gene

Also Known as DRS; ETX1; SRPX1; HEL-S-83p

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8406

About SRPX

Cytogenetic location: Xp11.4 Genomic coordinates (GRCh38): X:38,149,339-38,220,871 (from NCBI)

This gene has 6 transcripts (splice variants), 190 orthologues and 39 paralogues. Broad expression in placenta (RPKM 49.3), fat (RPKM 34.8) and 19 other tissues.

Summary

Predicted to be an extracellular matrix structural constituent. Predicted to be involved in cell adhesion. Predicted to act upstream of or within several processes, including negative regulation of cell proliferation involved in contact inhibition; phagolysosome assembly; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Part of collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

SRPX Products (4)

mRNA Protein Name
NM_001170750.2 NP_001164221.1 sushi repeat-containing protein SRPX isoform 2 precursor
NM_001170751.2 NP_001164222.1 sushi repeat-containing protein SRPX isoform 3 precursor
NM_001170752.2 NP_001164223.1 sushi repeat-containing protein SRPX isoform 4 precursor
NM_006307.5 NP_006298.1 sushi repeat-containing protein SRPX isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20406461 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRPX Protein Structure

Sushi

Sushi: Sushi repeat (SCR repeat) (69 - 112)

Sushi

Sushi: Sushi repeat (SCR repeat) (135 - 174)

HYR

HYR: HYR domain (175 - 257)

Sushi

Sushi: Sushi repeat (SCR repeat) (262 - 317)

DUF4174

DUF4174: Domain of unknown function (DUF4174) (332 - 452)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 464 a.a.
Protein Preferred Names Protein Names

sushi repeat-containing protein SRPX

  • epididymis secretory sperm binding protein Li 83p

Related Diseases

Diseases Alias
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13782 SRPX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13783 SRPX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17995 Srpx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19642 Srpx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24466 Srpx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26135 Srpx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SRPX RGD RGD:70950
Mus musculus SRPX MGD MGI:1858306
Bos taurus SRPX VGNC VGNC:50570
Others SRPX NCBI