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ZIC4 - Zic family member 4 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84107

About ZIC4

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:147,386,046-147,406,543 (from NCBI)

This gene has 17 transcripts (splice variants), 202 orthologues, 14 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding Zinc Finger Protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Dec 2009]

ZIC4 Products (4)

mRNA	Protein	Name
NM_001168378.1	NP_001161850.1	zinc finger protein ZIC 4 isoform 1 precursor
NM_001168379.2	NP_001161851.1	zinc finger protein ZIC 4 isoform 2
NM_001243256.2	NP_001230185.1	zinc finger protein ZIC 4 isoform 4
NM_032153.6	NP_115529.2	zinc finger protein ZIC 4 isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZIC4 Protein Structure

zf-C2H2_4

zf-H2C2_2

zf-C2H2

0
100
200
300
334 a.a.

Protein Preferred Names	Protein Names
zinc finger protein ZIC 4	zinc family member 4 protein HZIC4

ZIC4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89718	Zic4 Antibody (YA9062)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human

Related Diseases

Diseases	Alias
Isolated Dandy-Walker Malformation With Hydrocephalus
Isolated Dandy-Walker Malformation Without Hydrocephalus
Fallopian Tube Papillary Adenocarcinoma	Papillary Adenocarcinoma Of The Fallopian Tube
Cerebellar Malformation
Visceral Heterotaxy	Situs Ambiguus Heterotaxia Heterotaxy Syndrome Heterotaxy Lateralization Defect Situs Ambiguous Left Isomerism Htx Ivemark Syndrome Right Isomerism Situs Ambiguus Viscerum Incomplete Situs Inversus Partial Situs Inversus Heterotaxy, Visceral Asplenia Syndrome Bilateral Left-Sidedness Polysplenia Syndrome Moller Syndrome
Choroid Plexus Meningioma	Choroid Meningioma Meningioma Of The Choroid Plexus
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Intracranial Cavernous Angioma	Intracranial Cavernoma Intracranial Cavernous Hemangioma
Intracranial Structure Hemangioma	Angioma Of Intracranial Structure Hemangioma Of Intracranial Structure Hemangioma Of Intracranial Structures
Blepharophimosis, Ptosis, And Epicanthus Inversus	Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome BPES Blepharophimosis Syndrome Blepharophimosis, Epicanthus Inversus, And Ptosis, Type 1 Blepharophimosis, Ptosis, Epicanthus Inversus Syndrome Bpes With Duane Retraction Syndrome Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome Type 2 Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome Type 1 Blepharophimosis, Epicanthus Inversus, And Ptosis, Type 2 Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type 2 Bpes Type 2 Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Without Premature Ovarian Failure Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Plus 3q23 Microdeletion Syndrome Bpes Plus Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type 1 Bpes Type 1 Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome With Premature Ovarian Failure Blepharophimosis, Ptosis, Epicanthus Inversus Autosomal Dominant Bpes Type I Autosomal Recessive Bpes Type I Bpes Type I Bpes Type Ii Bpes Without Ovarian Failure Bpes With Ovarian Failure Blepharophimosis Syndrome Type 1 Blepharophimosis Syndrome Type 2
Ulnar Nerve Lesion	Lesion Of Ulnar Nerve Mononeuritis Ulnar Nerve Tardy Ulnar Nerve Palsy
Dandy-Walker Syndrome	Dandy-Walker Malformation DWS Atresia Of Foramina Of Magendie And Luschka Dandy-Walker Complex Dandy-Walker Cyst Dandy-Walker Deformity Dandy Walker Cyst Dw Complex Dandy-Walker Syndrome Or Malformation Dandy-Walker Variant Mega Cisterna Magna Dwm Hydrocephalus, Internal, Dandy-Walker Type Hydrocephalus, Noncommunicating, Dandy-Walker Type Luschka-Magendie Foramina Atresia Isolated Dandy-Walker Malformation Mega-Cisterna Magna Dandy Walker Variant Atresia Of Foramen Of Luschka Atresia Of Foramen Of Magendie Congenital Blockage Of Foramen Magendie

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16076	ZIC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZIC4	VGNC	VGNC:37187
Canis familiaris	ZIC4	VGNC	VGNC:49755
Macaca mulatta	ZIC4	VGNC	VGNC:79249
Felis catus	ZIC4	VGNC	VGNC:67248
Mus musculus	ZIC4	MGD	MGI:107201
Rattus norvegicus	ZIC4	RGD	RGD:1307298