WDR75 - WD repeat domain 75 Gene

Also Known as NET16; UTP17

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84128

About WDR75

This gene has 7 transcripts (splice variants), 207 orthologues and 26 paralogues. Ubiquitous expression in lymph node (RPKM 14.9), endometrium (RPKM 14.7) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

WDR75 Products (2)

mRNA Protein Name
NM_001303096.2 NP_001290025.1 WD repeat-containing protein 75 isoform 2
NM_032168.3 NP_115544.1 WD repeat-containing protein 75 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of rRNA processing IMP
IMP: Inferred from mutant phenotype
17699751 GOA
involved in positive regulation of transcription by RNA polymerase I IMP
IMP: Inferred from mutant phenotype
17699751 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
17699751 GOA
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR75 Protein Structure

WD40

WD40: WD domain, G-beta repeat (48 - 86)

WD40

WD40: WD domain, G-beta repeat (207 - 230)

WD40

WD40: WD domain, G-beta repeat (441 - 473)

  • 0
  • 200
  • 400
  • 600
  • 830 a.a.
Protein Preferred Names Protein Names

WD repeat-containing protein 75

  • U3 small nucleolar RNA-associated protein 17 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15796 WDR75 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris WDR75 VGNC VGNC:48387
Macaca mulatta WDR75 VGNC VGNC:79533
Mus musculus WDR75 MGD MGI:1920924
Felis catus WDR75 VGNC VGNC:67054
Rattus norvegicus WDR75 RGD RGD:1564869
Bos taurus WDR75 VGNC VGNC:36919