ZNF644 - zinc finger protein 644 Gene

Also Known as NatF; MYP21; ZEP-2; BM-005

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84146

About ZNF644

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:90,915,304-91,022,035 (from NCBI)

This gene has 11 transcripts (splice variants), 242 orthologues, 51 paralogues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 9.2), endometrium (RPKM 7.6) and 25 other tissues.

Summary

The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

ZNF644 Products (3)

mRNA	Protein	Name
NM_016620.4	NP_057704.2	zinc finger protein 644 isoform 2
NM_032186.5	NP_115562.3	zinc finger protein 644 isoform 2
NM_201269.3	NP_958357.1	zinc finger protein 644 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	25789554	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	25789554	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	29628311	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF644 Protein Structure

zf-C2H2_4

0
300
600
900
1200
1327 a.a.

Protein Preferred Names	Protein Names
zinc finger protein 644	zinc finger motif enhancer binding protein 2

Related Diseases

Diseases	Alias
Myopia 21, Autosomal Dominant	MYP21 Myopia, Type 21, Autosomal Dominant
Refractive Error	Refractive Errors
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted
Degenerative Myopia	Pathological Myopia Myopia, Degenerative Degenerative Progressive High Myopia Progressive High Myopia Progressive High Myopia
Anisometropia
Protoplasmic Astrocytoma	Protoplasmic Astrocytic Tumor Astrocytoma Protoplasmic
Stickler Syndrome	Arthroophthalmopathy Hereditary Arthro-Ophthalmo-Dystrophy Hereditary Arthro-Ophthalmopathy Stickler Dysplasia Hereditary Progressive Arthroophthalmopathy Stickler Syndrome, Type 1
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16162	ZNF644 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZNF644	MGD	MGI:1277212
Bos taurus	ZNF644	VGNC	VGNC:37320
Rattus norvegicus	ZNF644	RGD	RGD:1306805
Macaca mulatta	ZNF644	VGNC	VGNC:79789
Felis catus	ZNF644	VGNC	VGNC:67343
Canis familiaris	ZNF644	VGNC	VGNC:48784