LRRC8C - leucine rich repeat containing 8 VRAC subunit C Gene

Also Known as AD158; FAD158

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84230

About LRRC8C

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,615,824-89,719,533 (from NCBI)

This gene has 4 transcripts (splice variants), 203 orthologues and 31 paralogues. Ubiquitous expression in fat (RPKM 7.4), lymph node (RPKM 5.7) and 24 other tissues.

Summary

Enables volume-sensitive anion channel activity. Involved in cyclic-GMP-AMP transmembrane import across plasma membrane. Located in cytoplasm and plasma membrane. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRRC8C Products (1)

mRNA	Protein	Name
NM_032270.5	NP_115646.3	volume-regulated anion channel subunit LRRC8C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24790029	GOA
enables volume-sensitive anion channel activity	IMP IMP: Inferred from mutant phenotype	26824658	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cyclic-GMP-AMP transmembrane import across plasma membrane	IDA IDA: Inferred from direct assay	33171122	GOA
involved in monoatomic anion transmembrane transport	IMP IMP: Inferred from mutant phenotype	24790029	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24790029	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24790029	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	26824658	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC8C Protein Structure

Pannexin_like

LRR_8

LRR_1

0
200
400
600
803 a.a.

Protein Preferred Names	Protein Names
volume-regulated anion channel subunit LRRC8C	factor for adipocyte differentiation 158

Related Diseases

Diseases	Alias
Megalencephalic Leukoencephalopathy With Subcortical Cysts	Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts Mlc Van Der Knaap Disease Lvm Leukoencephalopathy With Swelling And Cysts Megalencephaly-Cystic Leukodystrophy Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome Infantile Leukoencephalopathy And Megalencephaly Leukoencephalopathy With Swelling And A Discrepantly Mild Course Vacuolating Leukoencephalopathy Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystrophy Syndrome Van Der Knaap Syndrome Leukoencephalopathy, Megalencephalic, With Subcortical Cysts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07829	LRRC8C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LRRC8C	VGNC	VGNC:81440
Bos taurus	LRRC8C	VGNC	VGNC:31031
Felis catus	LRRC8C	VGNC	VGNC:80269
Canis familiaris	LRRC8C	VGNC	VGNC:42816
Rattus norvegicus	LRRC8C	RGD	RGD:1306585
Mus musculus	LRRC8C	MGD	MGI:2140839
Others	LRRC8C	NCBI