LRRC8C - leucine rich repeat containing 8 VRAC subunit C Gene

Homo sapiens

Also known as AD158; FAD158

Gene ID: 84230 | Gene type: protein coding

About LRRC8C

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,615,824-89,719,533 (from NCBI)

This gene has 4 transcripts (splice variants), 203 orthologues and 31 paralogues. Ubiquitous expression in fat (RPKM 7.4), lymph node (RPKM 5.7) and 24 other tissues.

Summary

Enables volume-sensitive anion channel activity. Involved in cyclic-GMP-AMP transmembrane import across plasma membrane. Located in cytoplasm and plasma membrane. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRRC8C Products(1)

mRNA	Protein	Name
NM_032270.5	NP_115646.3	volume-regulated anion channel subunit LRRC8C

LRRC8C Protein Structure

Pannexin_like

LRR_8

LRR_1

0
200
400
600
803 a.a.

Protein Preferred Names

Protein Names

volume-regulated anion channel subunit LRRC8C

factor for adipocyte differentiation 158

Related Diseases

Diseases

Alias

Megalencephalic Leukoencephalopathy With Subcortical Cysts

Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts	Mlc
Van Der Knaap Disease	Lvm
Leukoencephalopathy With Swelling And Cysts	Megalencephaly-Cystic Leukodystrophy
Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome	Infantile Leukoencephalopathy And Megalencephaly
Leukoencephalopathy With Swelling And A Discrepantly Mild Course	Vacuolating Leukoencephalopathy
Megalencephalic Leukodystrophy	Megalencephaly-Cystic Leukodystrophy Syndrome
Van Der Knaap Syndrome	Leukoencephalopathy, Megalencephalic, With Subcortical Cysts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07829	LRRC8C Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LRRC8C	VGNC	VGNC:81440
Bos taurus	LRRC8C	VGNC	VGNC:31031
Felis catus	LRRC8C	VGNC	VGNC:80269
Canis familiaris	LRRC8C	VGNC	VGNC:42816
Rattus norvegicus	LRRC8C	RGD	RGD:1306585
Mus musculus	LRRC8C	MGD	MGI:2140839

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