SGIP1 - SH3GL interacting endocytic adaptor 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84251

About SGIP1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:66,533,361-66,751,139 (from NCBI)

This gene has 52 transcripts (splice variants), 282 orthologues and 5 paralogues. Biased expression in brain (RPKM 8.0), endometrium (RPKM 2.4) and 11 other tissues.

Summary

SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [PubMed 17626015]).[supplied by OMIM, Mar 2008]

SGIP1 Products (27)

mRNA Protein Name
NM_001308203.2 NP_001295132.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 2
NM_001350217.2 NP_001337146.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 3
NM_001350218.2 NP_001337147.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 4
NM_001376534.1 NP_001363463.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 1
NM_001376535.1 NP_001363464.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 1
NM_001376536.1 NP_001363465.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 2
NM_001376537.1 NP_001363466.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 5
NM_001376538.1 NP_001363467.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 6
NM_001376539.1 NP_001363468.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 7
NM_001376540.1 NP_001363469.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 7
NM_001376541.1 NP_001363470.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 8
NM_001376542.1 NP_001363471.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 8
NM_001376543.1 NP_001363472.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 8
NM_001376544.1 NP_001363473.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 9
NM_001376545.1 NP_001363474.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 9
NM_001376546.1 NP_001363475.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 10
NM_001376547.1 NP_001363476.1 SH3-containing GRB2-like protein 3-interacting protein 1 isofom 11
NM_001376548.1 NP_001363477.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 12
NM_001376549.1 NP_001363478.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 12
NM_001376550.1 NP_001363479.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 13
NM_001376551.1 NP_001363480.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 14
NM_001376552.1 NP_001363481.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 14
NM_001376554.1 NP_001363483.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 15
NM_001376555.1 NP_001363484.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 15
NM_001376556.1 NP_001363485.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 16
NM_001376557.1 NP_001363486.1 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 17
NM_032291.4 NP_115667.2 SH3-containing GRB2-like protein 3-interacting protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
20946875 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15919751 GOA
Cellular Component GO Annotation Evidence References Source
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
20946875 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
20946875 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SGIP1 Protein Structure

muHD

muHD: Muniscin C-terminal mu homology domain (560 - 826)

  • 0
  • 200
  • 400
  • 600
  • 828 a.a.
Protein Preferred Names Protein Names

SH3-containing GRB2-like protein 3-interacting protein 1

  • SH3 domain GRB2 like endophilin interacting protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12797 SGIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SGIP1 RGD RGD:1564957
Mus musculus SGIP1 MGD MGI:1920344
Bos taurus SGIP1 VGNC VGNC:34540
Canis familiaris SGIP1 VGNC VGNC:46096
Felis catus SGIP1 VGNC VGNC:65077
Macaca mulatta SGIP1 VGNC VGNC:77307
Others SGIP1 NCBI