2. Gene
  3. Gjb6 - gap junction protein, beta 6 Gene

Gjb6 - gap junction protein, beta 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cx30; Cxnf

Gene ID: 84403 | Gene type: protein coding

About Gjb6

Summary

Predicted to enable cytoskeletal protein binding activity and gap junction channel activity involved in cell communication by electrical coupling. Involved in several processes, including cellular response to glucose stimulus; response to electrical stimulus; and response to lipopolysaccharide. Located in apical plasma membrane; cytosol; and gap junction. Biomarker of borna disease; status epilepticus; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Human ortholog(s) of this gene implicated in Clouston syndrome; autosomal dominant nonsyndromic deafness 3B; autosomal recessive nonsyndromic deafness 1A; autosomal recessive nonsyndromic deafness 1B; and ectodermal dysplasia. Orthologous to human GJB6 (Gap Junction Protein beta 6). [provided by Alliance of Genome Resources, Apr 2022]

Gjb6 Products(2)

mRNA Protein Name
NM_001393806.1 NP_001380735.1 gap junction beta-6 protein
NM_053388.2 NP_445840.2 gap junction beta-6 protein
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
21567444 RGD
involved in inner ear development IEP
IEP: Inferred from expression pattern
10570462 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11238193 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
23149765 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
23023213 RGD
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16077080 RGD
located in gap junction IDA
IDA: Inferred from direct assay
10197766 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gap junction beta-6 protein

connexin f

gap junction membrane channel protein beta 6

gap junction protein, beta 6 (connexin 30)

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05451 GJB6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22184 Gjb6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gjb6 NCBI NCBI:10804