Slc17a6 - solute carrier family 17 member 6 Gene

Rattus norvegicus

Also known as Dnpi; Vglut2

Gene ID: 84487 | Gene type: protein coding

About Slc17a6

Summary

Enables L-glutamate transmembrane transporter activity. Involved in hippocampus development; neural retina development; and neurotransmitter loading into synaptic vesicle. Located in cytoplasmic vesicle; excitatory synapse; and pericellular basket. Is integral component of synaptic vesicle membrane. Biomarker of transient cerebral ischemia. Orthologous to human SLC17A6 (solute carrier family 17 member 6). [provided by Alliance of Genome Resources, Apr 2022]

Slc17a6 Products(1)

mRNA	Protein	Name
NM_053427.1	NP_445879.1	vesicular glutamate transporter 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-glutamate uniporter activity	IDA IDA: Inferred from direct assay	11502256	RGD
enables chloride channel activity	IDA IDA: Inferred from direct assay	27133463	RGD
enables potassium:proton antiporter activity	IDA IDA: Inferred from direct assay	25433636	RGD
enables sodium:phosphate symporter activity	IDA IDA: Inferred from direct assay	17046815	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	11502256	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	18502731	RGD
involved in neural retina development	IEP IEP: Inferred from expression pattern	18482716	RGD
involved in neurotransmitter loading into synaptic vesicle	IDA IDA: Inferred from direct assay	11502256	RGD
involved in neurotransmitter loading into synaptic vesicle	IMP IMP: Inferred from mutant phenotype	11502256	RGD
involved in phosphate ion transport	IDA IDA: Inferred from direct assay	29642010	RGD
involved in sodium-dependent phosphate transport	IDA IDA: Inferred from direct assay	17046815	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	11551935	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	16519671	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	11698619	RGD
located in pericellular basket	IDA IDA: Inferred from direct assay	18611437	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	11502256	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	18502731	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicular glutamate transporter 2

differentation-associated Na-dependent inorganic phosphate cotransporter	differentiation-associated BNPI
differentiation-associated Na(+)-dependent inorganic phosphate cotransporter	solute carrier family 17 (sodium-dependent inorganic phosphate cotrans

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13039	SLC17A6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc17a6	NCBI	NCBI:57084

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