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ACRBP - acrosin binding protein Gene

Also Known as CT23; SP32; OY-TES-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84519

About ACRBP

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,638,075-6,647,432 (from NCBI)

This gene has 9 transcripts (splice variants) and 118 orthologues. Restricted expression toward testis (RPKM 162.2).

Summary

The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the Cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]

ACRBP Products (1)

mRNA	Protein	Name
NM_032489.3	NP_115878.2	acrosin-binding protein precursor

ACRBP Protein Structure

PBP_sp32

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543 a.a.

Protein Preferred Names	Protein Names
acrosin-binding protein	acrosin-binding protein, 60 kDa form

Related Diseases

Diseases	Alias
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Cataract 9, Multiple Types	Cataract 9 Multiple Types CTRCT9 Cataract, Autosomal Dominant Catc1 Cataract 9, Multiple Types, With Or Without Microcornea Cataract, Autosomal Recessive Congenital 1 Autosomal Recessive Congenital Cataract 1 Cataract 9 Multiple Types With Or Without Microcornea Autosomal Dominant Congenital Cataract Cataract Autosomal Dominant Cataracts, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00194	ACRBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ACRBP	VGNC	VGNC:69445
Canis familiaris	ACRBP	VGNC	VGNC:37527
Mus musculus	ACRBP	MGD	MGI:1859515
Bos taurus	ACRBP	VGNC	VGNC:25558
Felis catus	ACRBP	VGNC	VGNC:59530
Rattus norvegicus	ACRBP	RGD	RGD:1564880
Others	ACRBP	NCBI