2. Gene
  3. Otof - otoferlin Gene

Otof - otoferlin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 84573 | Gene type: protein coding

About Otof

Summary

Predicted to enable AP-2 adaptor complex binding activity and calcium ion binding activity. Involved in cochlea development. Located in several cellular components, including apical part of cell; basal part of cell; and endoplasmic reticulum. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 9. Orthologous to human OTOF (otoferlin). [provided by Alliance of Genome Resources, Apr 2022]

Otof Products(1)

mRNA Protein Name
NM_001276720.1 NP_001263649.1 otoferlin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18772196 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
23719817 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cochlea development IEP
IEP: Inferred from expression pattern
17229086 RGD
Cellular Component GO Annotation Evidence Reference Source
located in apical part of cell IDA
IDA: Inferred from direct assay
23719817 RGD
located in basal part of cell IDA
IDA: Inferred from direct assay
23719817 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

otoferlin

fer-1-like protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09861 OTOF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Otof NCBI NCBI:9381