SLITRK2 - SLIT and NTRK like family member 2 Gene

Also Known as CXorf1; CXorf2; SLITL1; TMEM257

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84631

About SLITRK2

Cytogenetic location: Xq27.3 Genomic coordinates (GRCh38): X:145,817,829-145,829,856 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 25 paralogues. Biased expression in brain (RPKM 6.9), spleen (RPKM 1.8) and 2 other tissues.

Summary

This gene encodes an integral membrane protein that contains two N-terminal leucine-rich repeats domains and contains C-terminal regions similar to neurotrophin receptors. The encoded protein may play a role in modulating neurite activity. Alternatively spliced transcript variants encoding the same protein have been described.[provided by RefSeq, Feb 2010]

SLITRK2 Products (8)

mRNA	Protein	Name
NM_001144003.3	NP_001137475.1	SLIT and NTRK-like protein 2 precursor
NM_001144004.3	NP_001137476.1	SLIT and NTRK-like protein 2 precursor
NM_001144005.3	NP_001137477.1	SLIT and NTRK-like protein 2 precursor
NM_001144006.2	NP_001137478.1	SLIT and NTRK-like protein 2 precursor
NM_001144008.2	NP_001137480.1	SLIT and NTRK-like protein 2 precursor
NM_001144009.2	NP_001137481.1	SLIT and NTRK-like protein 2 precursor
NM_001144010.2	NP_001137482.1	SLIT and NTRK-like protein 2 precursor
NM_032539.5	NP_115928.1	SLIT and NTRK-like protein 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	35840571	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	35840571	GOA
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	23345436	GOA
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	23345436	GOA
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	27273464	GOA
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	27273464	GOA
involved in synaptic membrane adhesion	IDA IDA: Inferred from direct assay	23345436	GOA
involved in synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	23345436	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	23345436	GOA
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	23345436	GOA
located in dendrite	IDA IDA: Inferred from direct assay	35840571	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23345436	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23345436	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	35840571	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLITRK2 Protein Structure

LRR_8

LRR_1

LRR_8

LRR_1

0
200
400
600
800
845 a.a.

Protein Preferred Names	Protein Names
SLIT and NTRK-like protein 2	slit and trk like gene 2

Related Diseases

Diseases	Alias
Penile Benign Neoplasm	Neoplasm Of Penis Penile Tumor Cancer Of Penis Carcinoma Of Penis Malignant Neoplasm Of Penis, Unspecified Malignant Neoplasm Of Penis, Part Unspecified Malignant Tumour Of Penis Penile Cancer Primary Malignant Neoplasm Of Penis Malignant Neoplasm Of Skin Of Penis Nos
Trichotillomania	TTM Hair-Pulling Syndrome Compulsive Hair Plucking Hair Pulling Disorder
Supratentorial Primitive Neuroectodermal Tumor	Supratentorial Pnet Supratentorial Embryonal Tumor, Not Otherwise Specified Ewings Sarcoma-Primitive Neuroectodermal Tumor
Male Reproductive Organ Benign Neoplasm
Progesterone-Receptor Positive Breast Cancer
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13374	SLITRK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLITRK2	RGD	RGD:1561361
Bos taurus	SLITRK2	VGNC	VGNC:34963
Canis familiaris	SLITRK2	VGNC	VGNC:46507
Mus musculus	SLITRK2	MGD	MGI:2679449
Macaca mulatta	SLITRK2	VGNC	VGNC:77690