SUPT3H - SPT3 homolog, SAGA and STAGA complex component Gene

Also Known as SPT3; SPT3L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8464

About SUPT3H

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,809,057-45,377,934 (from NCBI)

This gene has 7 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 1.4), ovary (RPKM 1.0) and 24 other tissues.

Summary

Enables transcription coactivator activity. Involved in histone H3 acetylation and histone deubiquitination. Located in nucleoplasm. Part of SAGA complex and transcription factor TFTC complex. [provided by Alliance of Genome Resources, Apr 2022]

SUPT3H Products (8)

mRNA	Protein	Name
NM_001261823.2	NP_001248752.1	transcription initiation protein SPT3 homolog isoform 3
NM_001350324.2	NP_001337253.1	transcription initiation protein SPT3 homolog isoform 4
NM_001350325.2	NP_001337254.1	transcription initiation protein SPT3 homolog isoform 5
NM_001350326.2	NP_001337255.1	transcription initiation protein SPT3 homolog isoform 6
NM_001350327.2	NP_001337256.1	transcription initiation protein SPT3 homolog isoform 7
NM_001350329.2	NP_001337258.1	transcription initiation protein SPT3 homolog isoform 1
NM_003599.4	NP_003590.1	transcription initiation protein SPT3 homolog isoform 1
NM_181356.3	NP_852001.1	transcription initiation protein SPT3 homolog isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11564863	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9603525	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SAGA complex	IDA IDA: Inferred from direct assay	11564863	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9726987	GOA
part of transcription factor TFTC complex	IDA IDA: Inferred from direct assay	10373431	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUPT3H Protein Structure

TFIID-18kDa

0
100
200
300
328 a.a.

Protein Preferred Names	Protein Names
transcription initiation protein SPT3 homolog	SPT3-like protein

Related Diseases

Diseases	Alias
Cleidocranial Dysplasia	Cleidocranial Dysostosis CLCD Cleidocranial Dysplasia, Forme Fruste, Dental Anomalies Only Cleidocranial Dysplasia, Forme Fruste, With Brachydactyly CCD Marie-Sainton Disease Dysplasia Cleidocranial Dento-Osseous Dysplasia Marie-Sainton Syndrome Dysplasia, Cleidocranial
Hepatic Adenomas, Familial	Hepatic Adenoma, Somatic Familial Hepatic Adenoma Familial Liver Cell Adenomas Liver Cell Adenomas, Familial Hepatic Adenomas Familial HEPAF Ha Hepatocellular Adenomas Hepatocellular Adenoma
Malignant Giant Cell Tumor Of Soft Parts	Malignant Giant Cell Neoplasm Of Soft Parts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14036	SUPT3H Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SUPT3H	VGNC	VGNC:46990
Bos taurus	SUPT3H	VGNC	VGNC:35479
Mus musculus	SUPT3H	MGD	MGI:1923723
Macaca mulatta	SUPT3H	VGNC	VGNC:78055
Felis catus	SUPT3H	VGNC	VGNC:65847
Rattus norvegicus	SUPT3H	RGD	RGD:1591316
Others	SUPT3H	NCBI