INSM2 - INSM transcriptional repressor 2 Gene

Homo sapiens

Also known as IA6; IA-6; mlt1

Gene ID: 84684 | Gene type: protein coding

About INSM2

Cytogenetic location: 14q13.2 Genomic coordinates (GRCh38): 14:35,534,164-35,537,054 (from NCBI)

This gene has 1 transcript (splice variant), 167 orthologues and 1 paralogue.

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; neuron differentiation; and regulation of cell cycle process. Predicted to be located in cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

INSM2 Products(1)

mRNA	Protein	Name
NM_032594.4	NP_115983.3	insulinoma-associated protein 2

INSM2 Protein Structure

zf-C2H2

zf-C2H2_4

0
100
200
300
400
500
566 a.a.

Protein Preferred Names

Protein Names

insulinoma-associated protein 2

insulinoma-associated 2

Related Diseases

Diseases

Alias

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

Bleeding Disorder, Platelet-Type, 17

Platelet-Type Bleeding Disorder 17	BDPLT17
Thrombasthenia-Thrombocytopenia, Hereditary	Hereditary Thrombasthenia-Thrombocytopenia
Autosomal Dominant Macrothrombocytopenia Gfi1b-Related	Autosomal Dominant Platelet Disorder Gfi1b-Related
Bleeding Disorder, Platelet Type 17

Type 1 Diabetes Mellitus 5

Diabetes Mellitus, Insulin-Dependent, 5	Latent Autoimmune Diabetes In Adults
IDDM5	Insulin-Dependent Diabetes Mellitus 5
T1D5	Lada
Type 1.5 Diabetes	Diabetes Mellitus, Insulin-Dependent, Type 5

Type 1 Diabetes Mellitus 2

Diabetes Mellitus, Noninsulin-Dependent, 1	Diabetes Mellitus, Insulin-Dependent, 2
IDDM2	Insulin-Dependent Diabetes Mellitus 2
NIDDM1	Diabetes Mellitus, Noninsulin-Dependent 1
T1D2	Type 2 Diabetes Mellitus 1
T2D1	Noninsulin-Dependent Diabetes Mellitus 1
Diabetes Mellitus, Non-Insulin-Dependent, 1	Type 2 Diabetes Mellitus 1, Susceptibility To
Diabetes Mellitus, Insulin-Dependent, Type 2	Diabetes Mellitus, Non-Insulin-Dependent

Orthostatic Proteinuria

Postural Albuminuria

Arthrogryposis, Distal, Type 6

Distal Arthrogryposis Type 6	DA6
Arthrogryposis-Like Hand Anomaly-Sensorineural Deafness Syndrome	Arthrogryposis And Sensorineural Deafness
Familial Hand Abnormality And Sensori-Neural Deafness	Arthrogryposis-Like Hand Anomaly And Sensorineural Deafness
Arthrogryposis-Like Hand Anomaly-Sensorineural Hearing Loss Syndrome

Emphysematous Cholecystitis

Gaseous Pericholecystitis

Diabetes Mellitus, Ketosis-Prone

Diabetic Ketoacidosis	KPD
Diabetes Mellitus, Ketosis-Prone, Susceptibility To	Ketosis-Prone Diabetes Mellitus
Diabetes Mellitus, Insulin-Dependent	Diabetic Ketoacidosis Nos
Dka - [Diabetic Ketoacidosis] Nos	Dka - [Diabetic Ketoacidosis] Without Coma
Dka - [Diabetic Ketoacidosis] With Coma

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06845	INSM2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	INSM2	VGNC	VGNC:62934
Mus musculus	INSM2	MGD	MGI:1930787
Macaca mulatta	INSM2	VGNC	VGNC:73613
Rattus norvegicus	INSM2	RGD	RGD:1306949
Bos taurus	INSM2	VGNC	VGNC:106786
Canis familiaris	INSM2	VGNC	VGNC:42042

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