INSM2 - INSM transcriptional repressor 2 Gene

Also Known as IA6; IA-6; mlt1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84684

About INSM2

Cytogenetic location: 14q13.2 Genomic coordinates (GRCh38): 14:35,534,164-35,537,054 (from NCBI)

This gene has 1 transcript (splice variant), 167 orthologues and 1 paralogue.

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; neuron differentiation; and regulation of cell cycle process. Predicted to be located in cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

INSM2 Products (1)

mRNA Protein Name
NM_032594.4 NP_115983.3 insulinoma-associated protein 2

INSM2 Protein Structure

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (291 - 313)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (426 - 448)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (470 - 491)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (525 - 548)

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  • 566 a.a.
Protein Preferred Names Protein Names

insulinoma-associated protein 2

  • insulinoma-associated 2

Related Diseases

Diseases Alias
Insulinoma

  • Islet Cell Adenoma

  • Insulin-Producing Tumor Of Islet Cells

  • Adenoma Islet Cell

  • Islet Cell Tumor

  • Experimental Organism Islet Cell Adenoma Neoplasm
Bleeding Disorder, Platelet-Type, 17

  • Platelet-Type Bleeding Disorder 17

  • BDPLT17

  • Thrombasthenia-Thrombocytopenia, Hereditary

  • Hereditary Thrombasthenia-Thrombocytopenia

  • Autosomal Dominant Macrothrombocytopenia Gfi1b-Related

  • Autosomal Dominant Platelet Disorder Gfi1b-Related

  • Bleeding Disorder, Platelet Type 17
Type 1 Diabetes Mellitus 5

  • Diabetes Mellitus, Insulin-Dependent, 5

  • Latent Autoimmune Diabetes In Adults

  • IDDM5

  • Insulin-Dependent Diabetes Mellitus 5

  • T1D5

  • Lada

  • Type 1.5 Diabetes

  • Diabetes Mellitus, Insulin-Dependent, Type 5
Type 1 Diabetes Mellitus 2

  • Diabetes Mellitus, Noninsulin-Dependent, 1

  • Diabetes Mellitus, Insulin-Dependent, 2

  • IDDM2

  • Insulin-Dependent Diabetes Mellitus 2

  • NIDDM1

  • Diabetes Mellitus, Noninsulin-Dependent 1

  • T1D2

  • Type 2 Diabetes Mellitus 1

  • T2D1

  • Noninsulin-Dependent Diabetes Mellitus 1

  • Diabetes Mellitus, Non-Insulin-Dependent, 1

  • Type 2 Diabetes Mellitus 1, Susceptibility To

  • Diabetes Mellitus, Insulin-Dependent, Type 2

  • Diabetes Mellitus, Non-Insulin-Dependent
Orthostatic Proteinuria

  • Postural Albuminuria
Arthrogryposis, Distal, Type 6

  • Distal Arthrogryposis Type 6

  • DA6

  • Arthrogryposis-Like Hand Anomaly-Sensorineural Deafness Syndrome

  • Arthrogryposis And Sensorineural Deafness

  • Familial Hand Abnormality And Sensori-Neural Deafness

  • Arthrogryposis-Like Hand Anomaly And Sensorineural Deafness

  • Arthrogryposis-Like Hand Anomaly-Sensorineural Hearing Loss Syndrome
Emphysematous Cholecystitis

  • Gaseous Pericholecystitis
Diabetes Mellitus, Ketosis-Prone

  • Diabetic Ketoacidosis

  • KPD

  • Diabetes Mellitus, Ketosis-Prone, Susceptibility To

  • Ketosis-Prone Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetic Ketoacidosis Nos

  • Dka - [Diabetic Ketoacidosis] Nos

  • Dka - [Diabetic Ketoacidosis] Without Coma

  • Dka - [Diabetic Ketoacidosis] With Coma
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06845 INSM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22575 Insm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29093 Insm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus INSM2 VGNC VGNC:62934
Mus musculus INSM2 MGD MGI:1930787
Macaca mulatta INSM2 VGNC VGNC:73613
Rattus norvegicus INSM2 RGD RGD:1306949
Bos taurus INSM2 VGNC VGNC:106786
Canis familiaris INSM2 VGNC VGNC:42042