TRIM52 - tripartite motif containing 52 Gene

Also Known as RNF102

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84851

About TRIM52

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:181,249,062-181,261,143 (from NCBI)

This gene has 10 transcripts (splice variants), 175 orthologues and 80 paralogues. Ubiquitous expression in lymph node (RPKM 9.5), spleen (RPKM 9.1) and 25 other tissues.

Summary

Enables transcription coactivator activity and ubiquitin protein Ligase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and protein autoubiquitination. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TRIM52 Products (5)

mRNA Protein Name
NM_001346048.2 NP_001332977.1 E3 ubiquitin-protein ligase TRIM52 isoform 2
NM_001346049.2 NP_001332978.1 E3 ubiquitin-protein ligase TRIM52 isoform 3
NM_001346050.2 NP_001332979.1 E3 ubiquitin-protein ligase TRIM52 isoform 4
NM_001346051.2 NP_001332980.1 E3 ubiquitin-protein ligase TRIM52 isoform 5
NM_032765.4 NP_116154.1 E3 ubiquitin-protein ligase TRIM52 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
23077300 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
27667714 GOA
Biological Process GO Annotation Evidence References Source
involved in defense response to virus IDA
IDA: Inferred from direct assay
27667714 GOA
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
23077300 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
27667714 GOA
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
27667714 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
27667714 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
28073078 GOA
located in cytosol IDA
IDA: Inferred from direct assay
27667714 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27667714 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM52 Protein Structure

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (20 - 54)

zf-B_box

zf-B_box: B-box zinc finger (223 - 263)

  • 0
  • 100
  • 200
  • 297 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM52

  • RING finger protein 102

TRIM52 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89725 TRIM52 Antibody (YA9069) WB, IP, ELISA human

Related Diseases

Diseases Alias
Japanese Encephalitis

  • Japanese B Encephalitis

  • Je

  • Encephalitis Japanese

  • Encephalitis, Japanese

  • Russian Autumnal Encephalitis

  • Je - [Japanese Encephalitis]

  • Japanese Encephalitis Virus Disease

  • Jbe - [Japanese B Encephalitis}

  • B Type Encephalitis
Encephalitis

  • Mumps Encephalitis

  • Mumps Meningoencephalitis

  • Herpes Simplex Neuroinvasion

  • Herpetic Encephalitis

  • Herpetic Encephalopathy

  • Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

  • Encephalitis Due To Herpesviridae

  • Encephalitis Due To Herpesvirus

  • Herpes Encephalitis

  • Herpesviral Encephalitis

  • Herpes Simplex Encephalitis

  • Hsv - [Herpes Simplex Virus] Encephalitis

  • Herpes Virus Encephalitis

  • Simian B Disease

  • Simian B Disorder

  • Encephalitis Nec

  • Idiopathic Encephalitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15054 TRIM52 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TRIM52 VGNC VGNC:79172
Mus musculus TRIM52 MGD MGI:3045276
Canis familiaris TRIM52 VGNC VGNC:59045
Bos taurus TRIM52 VGNC VGNC:58617
Rattus norvegicus TRIM52 RGD RGD:1565615
Felis catus TRIM52 VGNC VGNC:102354
Others TRIM52 NCBI