USP45 - ubiquitin specific peptidase 45 Gene

Also Known as LCA19

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85015

About USP45

Cytogenetic location: 6q16.2 Genomic coordinates (GRCh38): 6:99,432,325-99,517,846 (from NCBI)

This gene has 13 transcripts (splice variants), 217 orthologues, 71 paralogues and is associated with 3 phenotypes. Ubiquitous expression in gall bladder (RPKM 1.4), small intestine (RPKM 1.4) and 25 other tissues.

Summary

The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair Endonuclease. This Endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016]

USP45 Products (13)

mRNA Protein Name
NM_001080481.3 NP_001073950.1 ubiquitin carboxyl-terminal hydrolase 45 isoform a
NM_001346021.3 NP_001332950.1 ubiquitin carboxyl-terminal hydrolase 45 isoform a
NM_001346022.3 NP_001332951.1 ubiquitin carboxyl-terminal hydrolase 45 isoform a
NM_001346023.3 NP_001332952.1 ubiquitin carboxyl-terminal hydrolase 45 isoform b
NM_001346024.3 NP_001332953.1 ubiquitin carboxyl-terminal hydrolase 45 isoform c
NM_001346025.3 NP_001332954.1 ubiquitin carboxyl-terminal hydrolase 45 isoform d
NM_001346026.3 NP_001332955.1 ubiquitin carboxyl-terminal hydrolase 45 isoform e
NM_001346027.3 NP_001332956.1 ubiquitin carboxyl-terminal hydrolase 45 isoform f
NM_001346028.3 NP_001332957.1 ubiquitin carboxyl-terminal hydrolase 45 isoform f
NM_001346029.3 NP_001332958.1 ubiquitin carboxyl-terminal hydrolase 45 isoform f
NM_001346030.2 NP_001332959.1 ubiquitin carboxyl-terminal hydrolase 45 isoform g
NM_001346033.2 NP_001332962.1 ubiquitin carboxyl-terminal hydrolase 45 isoform h
NM_032929.3 NP_116318.2 ubiquitin carboxyl-terminal hydrolase 45 isoform h

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
14715245 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
25538220 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25538220 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
25538220 GOA
involved in cell migration IMP
IMP: Inferred from mutant phenotype
30258100 GOA
acts upstream of or within protein deubiquitination IMP
IMP: Inferred from mutant phenotype
25538220 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25538220 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25538220 GOA
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
30573563 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP45 Protein Structure

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (62 - 138)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (190 - 810)

  • 0
  • 200
  • 400
  • 600
  • 814 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 45

  • deubiquitinating enzyme 45

Related Diseases

Diseases Alias
Leber Congenital Amaurosis 19

  • LCA19
Leber Plus Disease

  • Leber Congenital Amaurosis

  • Lca

  • Leber'S Amaurosis

  • Leber'S Disease

  • Amaurosis Congenita Of Leber

  • Amaurosis Congenita Of Leber, Type 1

  • Lhon Plus Disease

  • Congenital Absence Of The Rods And Cones

  • Congenital Retinal Blindness

  • Crb

  • Congenital Amaurosis Of Retinal Origin

  • Leber'S Congenital Amaurosis

  • Leber Congenital Amaurosis 1

  • Leber'S Congenital Tapetoretinal Degeneration

  • Leber'S Congenital Tapetoretinal Dysplasia

  • Lca1

  • Leber Congenital Amaurosis Type 1

  • Retinal Blindness, Congenital

  • Amaurosis, Leber Congenital

  • Dysgenesis Neuroepithelialis Retinae

  • Hereditary Epithelial Dysplasia Of Retina

  • Hereditary Retinal Aplasia

  • Heredoretinopathia Congenitalis

  • Leber Abiotrophy

  • Leber Congenital Tapetoretinal Degeneration

  • Lebers Congenital Amaurosis

  • Optic Atrophy, Hereditary, Leber
Uv-Sensitive Syndrome

  • Uvss

  • Uv Sensitive Syndrome

  • Ultraviolet Sensitive Syndrome
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15556 USP45 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22903 Usp45 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29417 Usp45 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus USP45 VGNC VGNC:66888
Rattus norvegicus USP45 RGD RGD:1310976
Bos taurus USP45 VGNC VGNC:52846
Macaca mulatta USP45 VGNC VGNC:79233
Mus musculus USP45 MGD MGI:101850
Canis familiaris USP45 VGNC VGNC:55015
Others USP45 NCBI