ACT1 - actin Gene

Also Known as ABY1; END7

Species: Saccharomyces cerevisiae S288C (strain: S288C)

Gene Type: protein coding
Gene ID: 850504

Summary

Enables ATP hydrolysis activity. A structural constituent of Cytoskeleton. Contributes to Histone Acetyltransferase activity. Involved in several processes, including ascospore wall assembly; mitotic actomyosin contractile ring contraction; and vacuole inheritance. Located in actin Cytoskeleton. Part of Ino80 complex; NuA4 Histone Acetyltransferase complex; and Swr1 complex. Used to study Moyamoya disease; autosomal dominant nonsyndromic deafness 20; patent ductus arteriosus; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome; artery disease (multiple); atrial heart septal defect 5; intrinsic cardiomyopathy (multiple); and myopathy (multiple). Orthologous to several human genes including ACTB (actin beta) and ACTG1 (actin gamma 1). [provided by Alliance of Genome Resources, Apr 2022]

ACT1 Products (1)

mRNA Protein Name
NM_001179927.1 NP_116614.1 TPA: actin [Saccharomyces cerevisiae S288C]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
8245125 SGD
enables structural constituent of cytoskeleton IDA
IDA: Inferred from direct assay
6217414 SGD
Biological Process GO Annotation Evidence References Source
involved in DNA repair IDA
IDA: Inferred from direct assay
16135807 SGD
involved in ascospore wall assembly IDA
IDA: Inferred from direct assay
17118118 SGD
involved in endocytosis IMP
IMP: Inferred from mutant phenotype
8590801 SGD
involved in establishment of cell polarity IGI
IGI: Inferred from genetic interaction
9864365 SGD
involved in mitotic actomyosin contractile ring contraction IMP
IMP: Inferred from mutant phenotype
9732290 SGD
involved in protein secretion IGI
IGI: Inferred from genetic interaction
10793147 SGD
involved in protein secretion IMP
IMP: Inferred from mutant phenotype
10793147 SGD
involved in vacuole inheritance IMP
IMP: Inferred from mutant phenotype
8978821 SGD
Cellular Component GO Annotation Evidence References Source
part of Ino80 complex IPI
IPI: Inferred from physical interaction
10952318 SGD
part of NuA4 histone acetyltransferase complex IDA
IDA: Inferred from direct assay
10911987 SGD
part of Swr1 complex IDA
IDA: Inferred from direct assay
14645854 SGD
located in actin cortical patch IDA
IDA: Inferred from direct assay
3967297 SGD
located in actin filament IDA
IDA: Inferred from direct assay
6217414 SGD
located in actin filament bundle IDA
IDA: Inferred from direct assay
3967297 SGD
located in cellular bud neck contractile ring IDA
IDA: Inferred from direct assay
3967297 SGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N9135 Quercetin 3,3'-dimethyl ether Inhibitor 99.04% Unkown
HY-P11197 ACT1 / Unkown
HY-RS14971 TRAF3IP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22078 Traf3ip2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown