ITGA10 - integrin subunit alpha 10 Gene

Also Known as PRO827

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8515

About ITGA10

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,891,208-145,910,050 (from NCBI)

This gene has 4 transcripts (splice variants), 223 orthologues and 17 paralogues. Broad expression in lung (RPKM 2.4), heart (RPKM 1.3) and 22 other tissues.

Summary

Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an Integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to Collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

ITGA10 Products (3)

mRNA	Protein	Name
NM_001303040.2	NP_001289969.1	integrin alpha-10 isoform 2
NM_001303041.2	NP_001289970.1	integrin alpha-10 isoform 3 precursor
NM_003637.5	NP_003628.2	integrin alpha-10 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables collagen binding involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	24823363	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	24823363	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24823363	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of integrin alpha10-beta1 complex	IDA IDA: Inferred from direct assay	24823363	GOA
part of integrin alpha10-beta1 complex	IPI IPI: Inferred from physical interaction	9685391	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGA10 Protein Structure

VWA

Integrin_alpha2

0
200
400
600
800
1000
1167 a.a.

Protein Preferred Names	Protein Names
integrin alpha-10

Related Diseases

Diseases	Alias
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Spinal Muscular Atrophy, Type Iv	SMA4 Spinal Muscular Atrophy, Adult Form Spinal Muscular Atrophy 4 Spinal Muscular Atrophy-4 Adult Spinal Muscular Atrophy Spinal Muscular Atrophy, Proximal, Adult, Autosomal Recessive Proximal Spinal Muscular Atrophy Type 4 Sma Type 4 Sma Type Iv Sma-Iv Sma Iv Spinal Muscular Atrophy Adult Form Spinal Muscular Atrophy Proximal Adult Autosomal Recessive Spinal Muscular Atrophy Type Iv Atrophy, Muscular, Spinal, Type Iv Myelopathic Muscular Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06946	ITGA10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26675	Itga10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20171	Itga10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ITGA10	VGNC	VGNC:42121
Rattus norvegicus	ITGA10	RGD	RGD:1305152
Felis catus	ITGA10	VGNC	VGNC:67837
Mus musculus	ITGA10	MGD	MGI:2153482
Bos taurus	ITGA10	VGNC	VGNC:30311
Macaca mulatta	ITGA10	VGNC	VGNC:73773
Others	ITGA10	NCBI