PIK3CB - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85243

About PIK3CB

Primary_assembly 8: 99,594,644-99,699,663 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 214 orthologues, 9 paralogues and is associated with 15 phenotypes. Biased expression in Kidney (RPKM 13.9), Lung (RPKM 81.4) and 9 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity. Involved in phosphatidylinositol phosphate biosynthetic process. Located in brush border membrane. Part of phosphatidylinositol 3-kinase complex. Used to study thrombosis. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

PIK3CB Products (2)

mRNA Protein Name
NM_053481.2 NP_445933.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
NM_053481.2 NP_445933.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol-3-kinase activity IDA
IDA: Inferred from direct assay
11931646 RGD
Biological Process GO Annotation Evidence References Source
involved in phosphatidylinositol phosphate biosynthetic process IDA
IDA: Inferred from direct assay
12882977 RGD
Cellular Component GO Annotation Evidence References Source
located in brush border membrane IDA
IDA: Inferred from direct assay
11931646 RGD
part of phosphatidylinositol 3-kinase complex IDA
IDA: Inferred from direct assay
12882977 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIK3CB Protein Structure

PI3K_p85B

PI3K_p85B: smart00143 (40 - 117)

PI3K_rbd

PI3K_rbd: smart00144 (179 - 287)

C2_PI3K_class_I_beta_delta

C2_PI3K_class_I_beta_delta: cd08693 (323 - 500)

PI3Ka_I

PI3Ka_I: cd00872 (531 - 701)

PI3Kc_IA_beta

PI3Kc_IA_beta: cd05173 (705 - 1066)

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  • 1000
  • 1070 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

  • PI3-kinase p110 subunit beta

  • PI3-kinase subunit beta

  • PI3K

  • PI3K-beta

  • PI3Kbeta

  • catalytic phosphatidylinositol 3-kinase beta

  • p110beta

  • phosphatidylinositol 3-kinase, catalytic, beta polypeptide

  • phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta

  • phosphoinositide-3-kinase, catalytic, beta polypeptide

  • ptdIns-3-kinase p110

  • ptdIns-3-kinase subunit beta

  • ptdIns-3-kinase subunit p110-beta

  • serine/threonine protein kinase PIK3CB

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-126077 MTI-31 Inhibitor 99.92% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10526 PIK3CB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10527 Pik3cb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10528 PIK3CB Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PIK3CB NCBI NCBI:5291