Cnga3 - cyclic nucleotide gated channel subunit alpha 3 Gene

Also Known as CNGgust

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85257

Summary

Enables cGMP binding activity; intracellular cGMP-activated cation channel activity; and protein C-terminus binding activity. Involved in several processes, including inorganic cation import across plasma membrane; response to cAMP; and response to magnesium ion. Located in several cellular components, including axon initial segment; glial cell projection; and perikaryon. Human ortholog(s) of this gene implicated in achromatopsia 2 and color blindness. Orthologous to human CNGA3 (cyclic nucleotide gated channel subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]

Cnga3 Products (2)

mRNA Protein Name
NM_001398686.1 NP_001385615.1 cyclic nucleotide-gated cation channel alpha-3 isoform 1
NM_001398687.1 NP_001385616.1 cyclic nucleotide-gated cation channel alpha-3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cGMP binding IDA
IDA: Inferred from direct assay
11387380 RGD
enables cadherin binding IPI
IPI: Inferred from physical interaction
23329832 RGD
enables intracellularly cGMP-activated cation channel activity IDA
IDA: Inferred from direct assay
11387380 RGD
enables myosin binding IPI
IPI: Inferred from physical interaction
23329832 RGD
Biological Process GO Annotation Evidence References Source
involved in inorganic cation import across plasma membrane IDA
IDA: Inferred from direct assay
9278419 RGD
involved in membrane depolarization IDA
IDA: Inferred from direct assay
15178415 RGD
involved in monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
11387380 RGD
involved in response to cAMP IDA
IDA: Inferred from direct assay
11387380 RGD
involved in response to magnesium ion IDA
IDA: Inferred from direct assay
11387380 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
15178415 RGD
Cellular Component GO Annotation Evidence References Source
located in axon initial segment IDA
IDA: Inferred from direct assay
18434027 RGD
located in dendrite IDA
IDA: Inferred from direct assay
18434027 RGD
located in glial cell projection IDA
IDA: Inferred from direct assay
18434027 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
18434027 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
12021210 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclic nucleotide-gated cation channel alpha-3

  • cyclic nucleotide gated channel alpha 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02881 CNGA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22449 Cnga3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cnga3 NCBI NCBI:1261