Cnga3 - cyclic nucleotide gated channel subunit alpha 3 Gene

Rattus norvegicus

Also known as CNGgust

Gene ID: 85257 | Gene type: protein coding

About Cnga3

Summary

Enables cGMP binding activity; intracellular cGMP-activated cation channel activity; and protein C-terminus binding activity. Involved in several processes, including inorganic cation import across plasma membrane; response to cAMP; and response to magnesium ion. Located in several cellular components, including axon initial segment; glial cell projection; and perikaryon. Human ortholog(s) of this gene implicated in achromatopsia 2 and color blindness. Orthologous to human CNGA3 (cyclic nucleotide gated channel subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]

Cnga3 Products(2)

mRNA	Protein	Name
NM_001398686.1	NP_001385615.1	cyclic nucleotide-gated cation channel alpha-3 isoform 1
NM_001398687.1	NP_001385616.1	cyclic nucleotide-gated cation channel alpha-3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cGMP binding	IDA IDA: Inferred from direct assay	11387380	RGD
enables cadherin binding	IPI IPI: Inferred from physical interaction	23329832	RGD
enables intracellularly cGMP-activated cation channel activity	IDA IDA: Inferred from direct assay	11387380	RGD
enables myosin binding	IPI IPI: Inferred from physical interaction	23329832	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in inorganic cation import across plasma membrane	IDA IDA: Inferred from direct assay	9278419	RGD
involved in membrane depolarization	IDA IDA: Inferred from direct assay	15178415	RGD
involved in monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	11387380	RGD
involved in response to cAMP	IDA IDA: Inferred from direct assay	11387380	RGD
involved in response to magnesium ion	IDA IDA: Inferred from direct assay	11387380	RGD
involved in sodium ion transport	IDA IDA: Inferred from direct assay	15178415	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon initial segment	IDA IDA: Inferred from direct assay	18434027	RGD
located in dendrite	IDA IDA: Inferred from direct assay	18434027	RGD
located in glial cell projection	IDA IDA: Inferred from direct assay	18434027	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	18434027	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	12021210	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cyclic nucleotide-gated cation channel alpha-3

cyclic nucleotide gated channel alpha 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02881	CNGA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22449	Cnga3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cnga3	NCBI	NCBI:1261

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