Cnga1 - cyclic nucleotide gated channel subunit alpha 1 Gene

Also Known as HCN; Cncg

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85259

Summary

Enables cGMP binding activity and intracellular cGMP-activated cation channel activity. Involved in membrane depolarization; regulation of cytosolic calcium ion concentration; and spermatogenesis. Located in cytoplasm and terminal bouton. Part of intracellular cyclic nucleotide activated cation channel complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 49. Orthologous to human CNGA1 (cyclic nucleotide gated channel subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Cnga1 Products (1)

mRNA Protein Name
NM_053497.2 NP_445949.2 cGMP-gated cation channel alpha-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cGMP binding IDA
IDA: Inferred from direct assay
18048449 RGD
enables intracellularly cGMP-activated cation channel activity IDA
IDA: Inferred from direct assay
18048449 RGD
Biological Process GO Annotation Evidence References Source
involved in membrane depolarization IDA
IDA: Inferred from direct assay
18048449 RGD
involved in regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
21809342 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
15713832 RGD
Cellular Component GO Annotation Evidence References Source
part of intracellular cyclic nucleotide activated cation channel complex IDA
IDA: Inferred from direct assay
12432397 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
21809342 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cGMP-gated cation channel alpha-1

  • CNG channel alpha-1

  • CNG-1

  • CNG1

  • cyclic nucleotide gated channel alpha 1

  • cyclic nucleotide-gated cation channel 1

  • cyclic nucleotide-gated channel, photoreceptor

  • rod photoreceptor cGMP-gated channel subunit alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02879 CNGA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cnga1 NCBI NCBI:1259