Slc25a27 - solute carrier family 25, member 27 Gene

Rattus norvegicus

Also known as Ucp4

Gene ID: 85262 | Gene type: protein coding

About Slc25a27

Summary

Involved in several processes, including cellular chemical homeostasis; negative regulation of mitochondrial membrane potential; and regulation of glucose import. Located in apical part of cell and neuronal cell body. Colocalizes with mitochondrion. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Apr 2022]

Slc25a27 Products(1)

mRNA	Protein	Name
NM_053500.2	NP_445952.1	mitochondrial uncoupling protein 4

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in inner ear development	IEP IEP: Inferred from expression pattern	21397696	RGD
involved in intracellular triglyceride homeostasis	IDA IDA: Inferred from direct assay	16716360	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	16716360	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16775390	RGD
involved in negative regulation of mitochondrial calcium ion concentration	IMP IMP: Inferred from mutant phenotype	16775390	RGD
involved in negative regulation of mitochondrial membrane potential	IDA IDA: Inferred from direct assay	21607879	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16716360	RGD
involved in regulation of D-glucose import	IDA IDA: Inferred from direct assay	21607879	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	21397696	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	21397696	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitochondrial uncoupling protein 4

uncoupling protein UCP-4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13108	SLC25A27 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc25a27	NCBI	NCBI:9481

Name
Email *

	Sorry, but the email address you supplied was invalid.