DGKD - diacylglycerol kinase delta Gene

Also Known as dgkd-2; DGKdelta; DGK-delta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8527

About DGKD

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,354,494-233,472,098 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 213 orthologues and 9 paralogues. Broad expression in stomach (RPKM 11.9), bone marrow (RPKM 9.9) and 23 other tissues.

Summary

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

DGKD Products (3)

mRNA Protein Name
NM_001377259.1 NP_001364188.1 diacylglycerol kinase delta isoform 3
NM_003648.3 NP_003639.2 diacylglycerol kinase delta isoform 1
NM_152879.3 NP_690618.2 diacylglycerol kinase delta isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent diacylglycerol kinase activity IDA
IDA: Inferred from direct assay
12200442 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
12084710 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
12200442 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
12810723 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12200442 GOA
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
12200442 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
12200442 GOA
Biological Process GO Annotation Evidence References Source
involved in diacylglycerol metabolic process IDA
IDA: Inferred from direct assay
12200442 GOA
involved in lipid phosphorylation IDA
IDA: Inferred from direct assay
17880279 GOA
involved in phosphatidic acid biosynthetic process IDA
IDA: Inferred from direct assay
17880279 GOA
involved in positive regulation of clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
17880279 GOA
Cellular Component GO Annotation Evidence References Source
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
17880279 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
12200442 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
12200442 GOA
located in cytosol IDA
IDA: Inferred from direct assay
12084710 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12084710 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGKD Protein Structure

PH

PH: PH domain (54 - 144)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (164 - 214)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (236 - 287)

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (321 - 446)

DAGK_acc

DAGK_acc: Diacylglycerol kinase accessory domain (763 - 920)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (1142 - 1205)

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  • 1214 a.a.
Protein Preferred Names Protein Names

diacylglycerol kinase delta

  • DAG kinase delta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03717 DGKD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DGKD VGNC VGNC:39917
Macaca mulatta DGKD VGNC VGNC:71783
Bos taurus DGKD VGNC VGNC:28026
Rattus norvegicus DGKD RGD RGD:1563309
Mus musculus DGKD MGD MGI:2138334
Felis catus DGKD VGNC VGNC:61459
Others DGKD NCBI