2. Gene
  3. KNDC1 - kinase non-catalytic C-lobe domain containing 1 Gene

KNDC1 - kinase non-catalytic C-lobe domain containing 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as v-KIND; RASGEF2; C10orf23; Very-KIND; bB439H18.3

Gene ID: 85442 | Gene type: protein coding

About KNDC1

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,160,219-133,226,412 (from NCBI)

This gene has 24 transcripts (splice variants) and 221 orthologues. Biased expression in brain (RPKM 6.5), ovary (RPKM 2.2) and 6 other tissues.

Summary

The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by Anti-aging therapies. [provided by RefSeq, Dec 2016]

KNDC1 Products(4)

mRNA Protein Name
NM_001347864.2 NP_001334793.1 kinase non-catalytic C-lobe domain-containing protein 1 isoform 2
NM_001347865.2 NP_001334794.1 kinase non-catalytic C-lobe domain-containing protein 1 isoform 3
NM_001347866.2 NP_001334795.1 kinase non-catalytic C-lobe domain-containing protein 1 isoform 4
NM_152643.8 NP_689856.6 kinase non-catalytic C-lobe domain-containing protein 1 isoform 1

KNDC1 Protein Structure

RasGEF_N

RasGEF_N: RasGEF N-terminal motif (1250 - 1348)

RasGEF

RasGEF: RasGEF domain (1466 - 1673)

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  • 1749 a.a.
Protein Preferred Names Protein Names

kinase non-catalytic C-lobe domain-containing protein 1

KIND domain-containing protein 1

Related Diseases

Diseases Alias
Joubert Syndrome 31

JBTS31
Brugada Syndrome 9

BRGDA9

Brugada Syndrome, Type 9
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07410 KNDC1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KNDC1 VGNC VGNC:82414
Mus musculus KNDC1 MGD MGI:1923734
Rattus norvegicus KNDC1 RGD RGD:1565261