TANC1 - tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 Gene

Also Known as TANC; ROLSB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85461

About TANC1

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:158,968,640-159,232,659 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 16.4), lung (RPKM 9.9) and 24 other tissues.

Summary

Predicted to be involved in regulation of postsynapse organization. Predicted to act upstream of or within dendritic spine maintenance; myoblast fusion; and visual learning. Predicted to be located in several cellular components, including axon terminus; neuronal cell body; and postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Apr 2022]

TANC1 Products (6)

mRNA Protein Name
NM_001145909.2 NP_001139381.1 protein TANC1 isoform 2
NM_001350062.2 NP_001336991.1 protein TANC1 isoform 3
NM_001350063.2 NP_001336992.1 protein TANC1 isoform 4
NM_001350064.2 NP_001336993.1 protein TANC1 isoform 5
NM_001350065.2 NP_001336994.1 protein TANC1 isoform 5
NM_033394.3 NP_203752.2 protein TANC1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30126976 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TANC1 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (912 - 995)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (1006 - 1108)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (1116 - 1208)

Ank

Ank: Ankyrin repeat (1210 - 1241)

TPR_11

TPR_11: TPR repeat (1291 - 1367)

TPR_2

TPR_2: Tetratricopeptide repeat (1371 - 1403)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1861 a.a.
Protein Preferred Names Protein Names

protein TANC1

  • TPR domain, ankyrin-repeat and coiled-coil-containing

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Dominant 41

  • MRD41

  • Autosomal Dominant Non-Syndromic Intellectual Disability 41

  • Mental Retardation, Autosomal Dominant 41

  • Autosomal Dominant Intellectual Developmental Disorder 41

  • Autosomal Dominant Mental Retardation 41

  • Mental Retardation, Autosomal Dominant, Type 41
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14194 TANC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TANC1 VGNC VGNC:35591
Macaca mulatta TANC1 VGNC VGNC:78238
Mus musculus TANC1 MGD MGI:1914110
Canis familiaris TANC1 VGNC VGNC:47098
Felis catus TANC1 VGNC VGNC:65948
Rattus norvegicus TANC1 RGD RGD:1302949
Others TANC1 NCBI