BNI1 - formin BNI1 Gene

Saccharomyces cerevisiae S288C (strain: S288C)

Also known as PPF3; SHE5

Gene ID: 855450 | Gene type: protein coding

About BNI1

Summary

Enables profilin binding activity. Involved in several processes, including budding cell apical bud growth; Cytoskeleton organization; and regulation of actin Cytoskeleton organization. Located in several cellular components, including actin filament; cellular bud tip; and mating projection tip. Part of incipient cellular bud site and polarisome. Human ortholog(s) of this gene implicated in primary ovarian insufficiency and primary ovarian insufficiency 2A. Orthologous to several human genes including DIAPH2 (diaphanous related formin 2). [provided by Alliance of Genome Resources, Apr 2022]

BNI1 Products(1)

mRNA	Protein	Name
NM_001183109.2	NP_014128.2	TPA: formin BNI1 [Saccharomyces cerevisiae S288C]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables profilin binding	IDA IDA: Inferred from direct assay	12134165	SGD
enables profilin binding	IMP IMP: Inferred from mutant phenotype	15923184	SGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament bundle assembly	IGI IGI: Inferred from genetic interaction	23671312	SGD
involved in actin filament bundle assembly	IMP IMP: Inferred from mutant phenotype	23671312	SGD
involved in actin nucleation	IDA IDA: Inferred from direct assay	12052901	SGD
involved in barbed-end actin filament capping	IDA IDA: Inferred from direct assay	14561409	SGD
involved in budding cell apical bud growth	IGI IGI: Inferred from genetic interaction	10866679	SGD
involved in budding cell apical bud growth	IMP IMP: Inferred from mutant phenotype	10866679	SGD
involved in cellular hyperosmotic response	IGI IGI: Inferred from genetic interaction	17237521	SGD
involved in cellular hyperosmotic response	IMP IMP: Inferred from mutant phenotype	17237521	SGD
involved in establishment of mitotic spindle orientation	IMP IMP: Inferred from mutant phenotype	10085293	SGD
involved in formin-nucleated actin cable assembly	IDA IDA: Inferred from direct assay	12134165	SGD
involved in formin-nucleated actin cable assembly	IGI IGI: Inferred from genetic interaction	11740491	SGD
involved in formin-nucleated actin cable assembly	IMP IMP: Inferred from mutant phenotype	11740491	SGD
involved in mitotic actomyosin contractile ring assembly	IGI IGI: Inferred from genetic interaction	12419188	SGD
involved in regulation of actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	17237521	SGD
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	17237521	SGD
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	10085294	SGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin filament	IDA IDA: Inferred from direct assay	12052901	SGD
located in cell division site	IDA IDA: Inferred from direct assay	26771880	SGD
located in cellular bud neck	IDA IDA: Inferred from direct assay	11154270	SGD
located in cellular bud tip	IDA IDA: Inferred from direct assay	11154270	SGD
is active in cellular bud tip	IMP IMP: Inferred from mutant phenotype	16166638	SGD
is active in cytosol	IDA IDA: Inferred from direct assay	38656798	SGD
located in incipient cellular bud site	IDA IDA: Inferred from direct assay	11154270	SGD
is active in mating projection tip	IDA IDA: Inferred from direct assay	38656798	SGD
located in mating projection tip	IDA IDA: Inferred from direct assay	9082982	SGD
part of polarisome	IDA IDA: Inferred from direct assay	9571251	SGD
part of polarisome	IPI IPI: Inferred from physical interaction	9571251	SGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

formin BNI1

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