KLF7 - KLF transcription factor 7 Gene

Also Known as UKLF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8609

About KLF7

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:207,074,137-207,173,851 (from NCBI)

This gene has 14 transcripts (splice variants), 270 orthologues, 22 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 4.7), endometrium (RPKM 4.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting Insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

KLF7 Products (4)

mRNA	Protein	Name
NM_001270942.1	NP_001257871.1	Krueppel-like factor 7 isoform 2
NM_001270943.2	NP_001257872.1	Krueppel-like factor 7 isoform 3
NM_001270944.2	NP_001257873.1	Krueppel-like factor 7 isoform 4
NM_003709.4	NP_003700.1	Krueppel-like factor 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9774444	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9774444	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9774444	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	16339272	GOA
involved in negative regulation of adipose tissue development	IMP IMP: Inferred from mutant phenotype	16339272	GOA
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	16339272	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16339272	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9774444	GOA
involved in regulation of epidermal cell differentiation	IMP IMP: Inferred from mutant phenotype	28916725	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	9774444	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLF7 Protein Structure

zf-H2C2_2

0
100
200
302 a.a.

Protein Preferred Names	Protein Names
Krueppel-like factor 7	Kruppel like factor 7

Related Diseases

Diseases	Alias
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07344	KLF7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19908	Klf7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26409	Klf7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KLF7	RGD	RGD:1306029
Macaca mulatta	KLF7	VGNC	VGNC:81188
Bos taurus	KLF7	VGNC	VGNC:50537
Felis catus	KLF7	VGNC	VGNC:67955
Mus musculus	KLF7	MGD	MGI:1935151
Canis familiaris	KLF7	VGNC	VGNC:54965
Others	KLF7	NCBI