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STX10 - syntaxin 10 Gene

Also Known as SYN10; hsyn10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8677

About STX10

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:13,144,058-13,150,375 (from NCBI)

This gene has 11 transcripts (splice variants), 89 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 17.6), spleen (RPKM 14.3) and 25 other tissues.

Summary

This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

STX10 Products (4)

mRNA	Protein	Name
NM_001271609.2	NP_001258538.1	syntaxin-10 isoform 2
NM_001271610.2	NP_001258539.1	syntaxin-10 isoform 3
NM_001271611.2	NP_001258540.1	syntaxin-10 isoform 4
NM_003765.3	NP_003756.1	syntaxin-10 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15878329	GOA
enables syntaxin binding	IPI IPI: Inferred from physical interaction	16154903	GOA

Biological Process GO Annotation	Evidence	References	Source
NOT involved in early endosome to Golgi transport	IDA IDA: Inferred from direct assay	16154903	GOA
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	16154903	GOA
involved in retrograde transport, endosome to Golgi	IDA IDA: Inferred from direct assay	18195106	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	9446797	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	9446797	GOA
located in vesicle	IDA IDA: Inferred from direct assay	15878329	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX10 Protein Structure

Syntaxin-6_N

SNARE

0
100
200
249 a.a.

Protein Preferred Names	Protein Names
syntaxin-10

Related Diseases

Diseases	Alias
Methemoglobinemia And Ambiguous Genitalia	METAG Methemoglobinemia Type Iv Isolated 17,20-Lyase Deficiency, Pure Methemoglobinemia Due To Deficiency Of Cytochrome B5 Methemoglobinemia Type 4 Methemoglobinemia Type Iv, Formerly Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly Pure Isolated 17,20-Lyase Deficiency Methemoglobinemia, Type Iv
Congenital Disorder Of Glycosylation, Type Iil	CDG2L Congenital Disorder Of Glycosylation Type Iil Cdg Iil Cog6-Cgd Cdgiil Cdg Syndrome Type Iil Congenital Disorder Of Glycosylation Type 2l Cdg-Iil Cdgiidl Congenital Disorder Of Glycosylation 2l Glycosylation, Congenital Disorder Of, Type Iil
Ceroid Lipofuscinosis, Neuronal, 10	Neuronal Ceroid Lipofuscinosis Due To Cathepsin D Deficiency Neuronal Ceroid Lipofuscinosis 10 CLN10 Cathepsin D Deficiency Congenital Neuronal Ceroid Lipofuscinosis Neuronal Ceroid Lipofuscinosis Cathepsin D-Deficient Cln10 Disease Ceroid Lipofuscinosis, Neuronal, Cathepsin D-Deficient Cln10 Disease, Adult Cln10 Disease, Congenital Cln10 Disease, Juvenile Cln10 Disease, Late Infantile Ceroid Lipofuscinosis Neuronal Cathepsin D-Deficient Cathepsin D Deficient Neuronal Ceroid Lipofuscinosis Congenital Ncl Lipofuscinosis, Ceroid, Neuronal, Type 10 Neuronal Ceroid Lipofuscinosis, Congenital

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13974	STX10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown