ENDOU - endonuclease, poly(U) specific Gene

Also Known as P11; PP11; PRSS26

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8909

About ENDOU

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:47,709,734-47,725,490 (from NCBI)

This gene has 4 transcripts (splice variants) and 211 orthologues. Biased expression in esophagus (RPKM 34.0), skin (RPKM 9.4) and 1 other tissue.

Summary

This gene encodes a protein with endoribonuclease activity that binds polyuridine-enriched single-stranded RNA. This gene was initially characterized based on its high expression in placenta but was mischaracterized as a serine protease. In mouse, this gene promotes tolerance to self-antigens by regulating B cell activation-induced cell death (AICD). The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

ENDOU Products (3)

mRNA	Protein	Name
NM_001172439.2	NP_001165910.1	uridylate-specific endoribonuclease isoform 1 precursor
NM_001172440.2	NP_001165911.1	uridylate-specific endoribonuclease isoform 3 precursor
NM_006025.4	NP_006016.1	uridylate-specific endoribonuclease isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	18936097	GOA
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	18936097	GOA
enables RNA endonuclease activity	IGI IGI: Inferred from genetic interaction	37803019	GOA
NOT enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	18936097	GOA
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	2350438	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in female pregnancy	IEP IEP: Inferred from expression pattern	2350438	GOA
involved in negative regulation of lipid catabolic process	IGI IGI: Inferred from genetic interaction	37803019	GOA
involved in post-transcriptional gene silencing	IGI IGI: Inferred from genetic interaction	37803019	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	2350438	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	6755403	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENDOU Protein Structure

Somatomedin_B

XendoU

0
100
200
300
410 a.a.

Protein Preferred Names	Protein Names
uridylate-specific endoribonuclease	22 serine protease

Related Diseases

Diseases	Alias
Rapp-Hodgkin Syndrome	RHS Anhidrotic Ectodermal Dysplasia With Cleft Lip/Palate Ectodermal Dysplasia, Rapp-Hodgkin Type Rapp-Hodgkin Ectodermal Dysplasia Syndrome Ectodermal Dysplasia, Anhidrotic, With Cleft Lip/Palate Ectodermal Dysplasia Syndrome, Rapp-Hodgkin Type Edrh Rapp-Hodgkin Ectodermal Dysplasia Orofacial Cleft 8
Noonan Syndrome 6	NS6 Noonan Syndrome, Type 6
Non-Gestational Choriocarcinoma	Choriocarcinoma, Non-Gestational

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04372	ENDOU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22486	Endou Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29009	Endou Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ENDOU	VGNC	VGNC:83873
Macaca mulatta	ENDOU	VGNC	VGNC:99925
Rattus norvegicus	ENDOU	RGD	RGD:1593011
Mus musculus	ENDOU	MGD	MGI:97746
Others	ENDOU	NCBI