Lbr - lamin B receptor Gene

Also Known as C14SR; Nbp60

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 89789

Summary

Enables chaperone binding activity and nuclear localization sequence binding activity. Involved in mitotic cell cycle. Located in cytoplasm and nuclear envelope. Part of nuclear pore. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor). [provided by Alliance of Genome Resources, Apr 2022]

Lbr Products (1)

mRNA Protein Name
NM_001393665.1 NP_001380594.1 delta(14)-sterol reductase LBR

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear localization sequence binding IPI
IPI: Inferred from physical interaction
8486604 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9192729 RGD
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
8486604 RGD
Cellular Component GO Annotation Evidence References Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
8598227 RGD
part of nuclear pore IDA
IDA: Inferred from direct assay
12438562 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

delta(14)-sterol reductase LBR

  • 3-beta-hydroxysterol Delta (14)-reductase

  • C-14 sterol reductase

  • delta-14-SR

  • integral nuclear envelope inner membrane protein

  • sterol C14-reductase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99019 Fremanezumab Inhibitor 95.00% Unkown

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07545 LBR Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lbr NCBI NCBI:3930