Picalm - phosphatidylinositol binding clathrin assembly protein Gene

Also Known as Calm

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 89816

Summary

Enables several functions, including SH3 domain binding activity; identical protein binding activity; and phosphatidylinositol binding activity. Involved in several processes, including generation of neurons; positive regulation of dendrite extension; and positive regulation of transport. Located in several cellular components, including cytoplasmic vesicle; postsynaptic density; and synaptic membrane. Is intrinsic component of membrane. Is active in Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and postsynapse. Is extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein). [provided by Alliance of Genome Resources, Apr 2022]

Picalm Products (1)

mRNA Protein Name
NM_053554.2 NP_446006.1 phosphatidylinositol-binding clathrin assembly protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol binding IDA
IDA: Inferred from direct assay
11161218 RGD
enables SH3 domain binding IDA
IDA: Inferred from direct assay
10926122 RGD
enables SNARE binding IPI
IPI: Inferred from physical interaction
21808019 RGD
enables clathrin binding IDA
IDA: Inferred from direct assay
11161218 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
22118466 RGD
enables phosphatidylinositol-4,5-bisphosphate binding IMP
IMP: Inferred from mutant phenotype
25898166 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
22118466 RGD
Biological Process GO Annotation Evidence References Source
involved in axonogenesis IMP
IMP: Inferred from mutant phenotype
18842885 RGD
involved in clathrin coat assembly IDA
IDA: Inferred from direct assay
11190274 RGD
involved in dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
18842885 RGD
involved in positive regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
18842885 RGD
involved in positive regulation of dendrite extension IMP
IMP: Inferred from mutant phenotype
18842885 RGD
involved in positive regulation of synaptic vesicle clustering IMP
IMP: Inferred from mutant phenotype
22851330 RGD
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
21808019 RGD
involved in regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
18842885 RGD
involved in regulation of protein transport IMP
IMP: Inferred from mutant phenotype
18842885 RGD
involved in regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
18842885 RGD
involved in regulation of synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
18842885 RGD
involved in regulation of terminal button organization IMP
IMP: Inferred from mutant phenotype
22851330 RGD
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
21808019 RGD
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
21808019 RGD
involved in vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
18842885 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
15558718 RGD
located in clathrin-coated vesicle IDA
IDA: Inferred from direct assay
11190274 RGD
located in endosome IDA
IDA: Inferred from direct assay
18842885 RGD
is active in extrinsic component of presynaptic endocytic zone membrane IDA
IDA: Inferred from direct assay
15558718 RGD
located in membrane IMP
IMP: Inferred from mutant phenotype
25898166 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
18842885 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
15558718 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
18842885 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
15558718 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
17640037 RGD
is active in postsynaptic endocytic zone IDA
IDA: Inferred from direct assay
35072626 RGD
is active in postsynaptic endocytic zone IMP
IMP: Inferred from mutant phenotype
35072626 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
15558718 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
15558718 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
17640037 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylinositol-binding clathrin assembly protein

  • clathrin-assembly lymphoid leukemia protein

  • clathrin-assembly lymphoid myeloid leukemia protein

  • rCALM

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10478 PICALM Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Picalm NCBI NCBI:8301