Picalm - phosphatidylinositol binding clathrin assembly protein Gene

Rattus norvegicus

Also known as Calm

Gene ID: 89816 | Gene type: protein coding

About Picalm

Summary

Enables several functions, including SH3 domain binding activity; identical protein binding activity; and phosphatidylinositol binding activity. Involved in several processes, including generation of neurons; positive regulation of dendrite extension; and positive regulation of transport. Located in several cellular components, including cytoplasmic vesicle; postsynaptic density; and synaptic membrane. Is intrinsic component of membrane. Is active in Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and postsynapse. Is extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein). [provided by Alliance of Genome Resources, Apr 2022]

Picalm Products(1)

mRNA	Protein	Name
NM_053554.2	NP_446006.1	phosphatidylinositol-binding clathrin assembly protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol binding	IDA IDA: Inferred from direct assay	11161218	RGD
enables SH3 domain binding	IDA IDA: Inferred from direct assay	10926122	RGD
enables SNARE binding	IPI IPI: Inferred from physical interaction	21808019	RGD
enables clathrin binding	IDA IDA: Inferred from direct assay	11161218	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	22118466	RGD
enables phosphatidylinositol-4,5-bisphosphate binding	IMP IMP: Inferred from mutant phenotype	25898166	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	22118466	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	18842885	RGD
involved in clathrin coat assembly	IDA IDA: Inferred from direct assay	11190274	RGD
involved in dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	18842885	RGD
involved in positive regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	18842885	RGD
involved in positive regulation of dendrite extension	IMP IMP: Inferred from mutant phenotype	18842885	RGD
involved in positive regulation of synaptic vesicle clustering	IMP IMP: Inferred from mutant phenotype	22851330	RGD
involved in positive regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	21808019	RGD
involved in regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	18842885	RGD
involved in regulation of protein transport	IMP IMP: Inferred from mutant phenotype	18842885	RGD
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	18842885	RGD
involved in regulation of synaptic vesicle transport	IMP IMP: Inferred from mutant phenotype	18842885	RGD
involved in regulation of terminal button organization	IMP IMP: Inferred from mutant phenotype	22851330	RGD
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	21808019	RGD
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	21808019	RGD
involved in vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	18842885	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	15558718	RGD
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	11190274	RGD
located in endosome	IDA IDA: Inferred from direct assay	18842885	RGD
is active in extrinsic component of presynaptic endocytic zone membrane	IDA IDA: Inferred from direct assay	15558718	RGD
located in membrane	IMP IMP: Inferred from mutant phenotype	25898166	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	18842885	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	15558718	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	18842885	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	15558718	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	17640037	RGD
is active in postsynaptic endocytic zone	IDA IDA: Inferred from direct assay	35072626	RGD
is active in postsynaptic endocytic zone	IMP IMP: Inferred from mutant phenotype	35072626	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	15558718	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	15558718	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	17640037	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phosphatidylinositol-binding clathrin assembly protein

clathrin-assembly lymphoid leukemia protein	clathrin-assembly lymphoid myeloid leukemia protein
rCALM

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10478	PICALM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Picalm	NCBI	NCBI:8301

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