ARHGAP11B - Rho GTPase activating protein 11B Gene

Also Known as B'-T; FAM7B1; GAP (1-8)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 89839

About ARHGAP11B

Cytogenetic location: 15q13.2 Genomic coordinates (GRCh38): 15:30,626,128-30,649,229 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 244 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 7.6), lymph node (RPKM 4.9) and 16 other tissues.

Summary

Predicted to enable GTPase activator activity. Involved in cerebral cortex development and negative regulation of mitochondrial membrane permeability. Acts upstream of with a positive effect on glutamine catabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

ARHGAP11B Products (1)

mRNA Protein Name
NM_001039841.3 NP_001034930.1 inactive Rho GTPase-activating protein 11B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables GTPase activator activity IDA
IDA: Inferred from direct assay
25721503 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31883789 GOA
Biological Process GO Annotation Evidence References Source
involved in cerebral cortex development IDA
IDA: Inferred from direct assay
25721503 GOA
acts upstream of positive effect glutamine catabolic process IDA
IDA: Inferred from direct assay
31883789 GOA
involved in negative regulation of mitochondrial membrane permeability IDA
IDA: Inferred from direct assay
31883789 GOA
NOT involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
27957544 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
31883789 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP11B Protein Structure

RhoGAP

RhoGAP: RhoGAP domain (66 - 209)

  • 0
  • 100
  • 200
  • 267 a.a.
Protein Preferred Names Protein Names

inactive Rho GTPase-activating protein 11B

  • family with sequence similarity 7, member B1

Related Diseases

Diseases Alias
Chromosome 15q13.3 Deletion Syndrome

  • Chromosome 15q13.3 Microdeletion Syndrome

  • 15q13.3 Microdeletion Syndrome

  • 15q13.3 Microdeletion

  • Microdeletion 15q13.3 Syndrome

  • Del(15)(Q13.3)

  • Monosomy 15q13.3
Interstitial Nephritis, Karyomegalic

  • Karyomegalic Interstitial Nephritis

  • KMIN

  • Kin

  • Systemic Karyomegaly

  • Karyomegalic Tubulointerstitial Nephritis

  • Ktn
Benign Epilepsy With Centrotemporal Spikes

  • Rolandic Epilepsy

  • Benign Rolandic Epilepsy

  • Epilepsy, Rolandic

  • Bcects

  • Benign Childhood Epilepsy With Centrotemporal Spike

  • Sylvan Seizures

  • Becrs

  • Bects

  • Bre

  • Benign Epilepsy Of Childhood With Centrotemporal Spikes

  • Benign Familial Epilepsy Of Childhood With Rolandic Spikes

  • Centrotemporal Epilepsy
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00914 ARHGAP11B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ARHGAP11B MGD MGI:2444300