ERI1 - exoribonuclease 1 Gene

Also Known as HEXO; THEX1; 3'HEXO

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90459

About ERI1

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:9,002,897-9,100,104 (from NCBI)

This gene has 9 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 5.2), appendix (RPKM 4.2) and 25 other tissues.

Summary

Enables 3'-5' exonuclease activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

ERI1 Products (4)

mRNA Protein Name
NM_001354635.2 NP_001341564.1 3'-5' exoribonuclease 1 isoform 3
NM_001354636.2 NP_001341565.1 3'-5' exoribonuclease 1 isoform 4
NM_001354638.2 NP_001341567.1 3'-5' exoribonuclease 1 isoform 2
NM_153332.4 NP_699163.2 3'-5' exoribonuclease 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables 3'-5' exonuclease activity IDA
IDA: Inferred from direct assay
14536070 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23329046 GOA
Biological Process GO Annotation Evidence Verweise Source
NOT involved in histone mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
18172165 GOA
involved in maturation of 5.8S rRNA IMP
IMP: Inferred from mutant phenotype
37352860 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16912046 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
16912046 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERI1 Protein Structure

SAP

SAP: SAP domain (77 - 109)

RNase_T

RNase_T: Exonuclease (132 - 305)

  • 0
  • 100
  • 200
  • 300
  • 349 a.a.
Protein Preferred Names Protein Names

3'-5' exoribonuclease 1

  • 3' exoribonuclease

Related Diseases

Diseases Alias
Renal Hypodysplasia/Aplasia 3

  • RHDA3

  • Renal Agenesis, Unilateral

  • Unilateral Renal Agenesis
Locked-In Syndrome

  • Locked In Syndrome

  • Cerebromedullospinal Disconnection

  • Locked-In State

  • Quadriplegia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04496 ERI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ERI1 MGD MGI:1914526
Canis familiaris ERI1 VGNC VGNC:40454
Macaca mulatta ERI1 VGNC VGNC:72324
Rattus norvegicus ERI1 RGD RGD:1308378
Felis catus ERI1 VGNC VGNC:61943
Others ERI1 NCBI