ERI1 - exoribonuclease 1 Gene

Homo sapiens

Also known as HEXO; THEX1; 3'HEXO

Gene ID: 90459 | Gene type: protein coding

About ERI1

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:9,002,897-9,100,104 (from NCBI)

This gene has 9 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 5.2), appendix (RPKM 4.2) and 25 other tissues.

Summary

Enables 3'-5' exonuclease activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

ERI1 Products(4)

mRNA	Protein	Name
NM_001354635.2	NP_001341564.1	3'-5' exoribonuclease 1 isoform 3
NM_001354636.2	NP_001341565.1	3'-5' exoribonuclease 1 isoform 4
NM_001354638.2	NP_001341567.1	3'-5' exoribonuclease 1 isoform 2
NM_153332.4	NP_699163.2	3'-5' exoribonuclease 1 isoform 1

ERI1 Protein Structure

SAP

RNase_T

0
100
200
300
349 a.a.

Protein Preferred Names

Protein Names

3'-5' exoribonuclease 1

3' exoribonuclease

Related Diseases

Diseases

Alias

Renal Hypodysplasia/Aplasia 3

RHDA3	Renal Agenesis, Unilateral
Unilateral Renal Agenesis

Locked-In Syndrome

Locked In Syndrome	Cerebromedullospinal Disconnection
Locked-In State	Quadriplegia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04496	ERI1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ERI1	MGD	MGI:1914526
Canis familiaris	ERI1	VGNC	VGNC:40454
Macaca mulatta	ERI1	VGNC	VGNC:72324
Rattus norvegicus	ERI1	RGD	RGD:1308378
Felis catus	ERI1	VGNC	VGNC:61943