PLXNA4 - plexin A4 Gene

Also Known as PLEXA4; PLXNA4A; PLXNA4B; FAYV2820; PRO34003

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91584

About PLXNA4

Cytogenetic location: 7q32.3 Genomic coordinates (GRCh38): 7:132,123,340-132,648,688 (from NCBI)

This gene has 5 transcripts (splice variants), 227 orthologues and 8 paralogues. Broad expression in fat (RPKM 7.3), brain (RPKM 3.4) and 14 other tissues.

Summary

Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including axon guidance; positive regulation of axonogenesis; and regulation of GTPase activity. Predicted to act upstream of or within several processes, including nervous system development; regulation of axon extension involved in axon guidance; and regulation of negative chemotaxis. Predicted to be located in plasma membrane. Predicted to be part of semaphorin receptor complex. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLXNA4 Products (4)

mRNA Protein Name
NM_001105543.2 NP_001099013.1 plexin-A4 isoform 3 precursor
NM_001393897.1 NP_001380826.1 plexin-A4 isoform 1 precursor
NM_020911.2 NP_065962.1 plexin-A4 isoform 1 precursor
NM_181775.4 NP_861440.2 plexin-A4 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLXNA4 Protein Structure

Sema

Sema: Sema domain (51 - 489)

PSI

PSI: Plexin repeat (509 - 558)

PSI

PSI: Plexin repeat (655 - 702)

PSI

PSI: Plexin repeat (804 - 855)

TIG

TIG: IPT/TIG domain (858 - 938)

TIG

TIG: IPT/TIG domain (955 - 1036)

TIG

TIG: IPT/TIG domain (1040 - 1138)

TIG

TIG: IPT/TIG domain (1156 - 1218)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1311 - 1864)

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  • 1800
  • 1894 a.a.
Protein Preferred Names Protein Names

plexin-A4

  • epididymis secretory sperm binding protein

Related Diseases

Diseases Alias
Hypogonadotropic Hypogonadism 16 With Or Without Anosmia

  • HH16

  • Hypogonadism, Hypogonadotropic, Type 16 With/Without Anosmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10751 PLXNA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PLXNA4 VGNC VGNC:33060
Rattus norvegicus PLXNA4 RGD RGD:1308074
Macaca mulatta PLXNA4 VGNC VGNC:76186
Canis familiaris PLXNA4 VGNC VGNC:44721
Mus musculus PLXNA4 MGD MGI:2179061
Felis catus PLXNA4 VGNC VGNC:68917
Others PLXNA4 NCBI