SYT12 - synaptotagmin 12 Gene

Also Known as SYT11; sytXII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91683

About SYT12

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,006,771-67,050,863 (from NCBI)

This gene has 7 transcripts (splice variants), 191 orthologues and 31 paralogues. Biased expression in brain (RPKM 5.6), liver (RPKM 2.3) and 5 other tissues.

Summary

This gene is a member of the synaptotagmin gene family and encodes a protein similar to Other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.[provided by RefSeq, Apr 2010]

SYT12 Products (4)

mRNA Protein Name
NM_001177880.2 NP_001171351.1 synaptotagmin-12 isoform a
NM_001318773.2 NP_001305702.1 synaptotagmin-12 isoform b
NM_001318775.2 NP_001305704.1 synaptotagmin-12 isoform b
NM_177963.4 NP_808878.1 synaptotagmin-12 isoform a

SYT12 Protein Structure

C2

C2: C2 domain (169 - 254)

C2

C2: C2 domain (300 - 387)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 421 a.a.
Protein Preferred Names Protein Names

synaptotagmin-12

  • synaptotagmin-XII

Related Diseases

Diseases Alias
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14108 SYT11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14109 SYT12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SYT12 VGNC VGNC:65894
Macaca mulatta SYT12 VGNC VGNC:78159
Mus musculus SYT12 MGD MGI:2159601
Canis familiaris SYT12 VGNC VGNC:47043
Bos taurus SYT12 VGNC VGNC:35538
Rattus norvegicus SYT12 RGD RGD:621876
Others SYT12 NCBI