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SCAF11 - SR-related CTD associated factor 11 Gene

Also Known as SIP1; CASP11; SFRS2IP; SRRP129; SRSF2IP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9169

About SCAF11

Cytogenetic location: 12q12 Genomic coordinates (GRCh38): 12:45,919,131-45,992,059 (from NCBI)

This gene has 15 transcripts (splice variants), 203 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 15.2), appendix (RPKM 14.4) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in spliceosomal complex assembly. Located in nuclear body and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

SCAF11 Products (1)

mRNA	Protein	Name
NM_004719.3	NP_004710.2	protein SCAF11

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9447963	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RNA splicing	IDA IDA: Inferred from direct assay	9447963	GOA
involved in RNA splicing, via transesterification reactions	IDA IDA: Inferred from direct assay	9447963	GOA
involved in spliceosomal complex assembly	IDA IDA: Inferred from direct assay	9447963	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCAF11 Protein Structure

zf-RING_2

0
300
600
900
1200
1463 a.a.

Protein Preferred Names	Protein Names
protein SCAF11	CTD-associated SR protein 11

Related Diseases

Diseases	Alias
Corneal Endothelial Dystrophy	Congenital Hereditary Endothelial Dystrophy Of Cornea Chandler Syndrome CHED Chandler'S Syndrome Endothelial Corneal Dystrophy Ched2 Maumenee Corneal Dystrophy Corneal Dystrophy, Congenital Hereditary Endothelial Dystrophy Of Corneal Endothelium Corneal Endothelial Dystrophy 2 Corneal Endothelial Dystrophy 2, Autosomal Recessive, Formerly Ched2, Formerly Corneal Endothelial Dystrophy, Autosomal Recessive Endothelial Dystrophy Posterior Membrane Corneal Dystrophy Corneal Endothelial Dystrophy Type 2 Congenital Hereditary Endothelial Dystrophy Of The Cornea Congenital Hereditary Endothelial Dystrophy Type Ii Autosomal Recessive Ched Autosomal Recessive Congenital Hereditary Endothelial Dystrophy Chedii Congenital Hereditary Endothelial Dystrophy Type 2 Infantile Hereditary Endothelial Dystrophy Congenital Hereditary Endothelial Corneal Dystrophy Corneal Endothelial Dystrophy 2, Autosomal Recessive Iridocorneal Endothelial Syndrome Dystrophy, Corneal, Endothelial Corneal Endothelial Dystrophy 1, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12475	SCAF11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SCAF11	MGD	MGI:1919443
Felis catus	SCAF11	VGNC	VGNC:64892
Bos taurus	SCAF11	VGNC	VGNC:34314
Rattus norvegicus	SCAF11	RGD	RGD:1598325
Macaca mulatta	SCAF11	VGNC	VGNC:77002
Canis familiaris	SCAF11	VGNC	VGNC:45889
Others	SCAF11	NCBI